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澳大利亚西部奥克维尔病毒株 K13965 的遗传特征。

Genetic characterization of K13965, a strain of Oak Vale virus from Western Australia.

机构信息

Center for Infection and Immunity, Columbia University, New York, NY 10032, USA.

出版信息

Virus Res. 2011 Sep;160(1-2):206-13. doi: 10.1016/j.virusres.2011.06.021. Epub 2011 Jun 29.

DOI:10.1016/j.virusres.2011.06.021
PMID:21740935
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3174045/
Abstract

K13965, an uncharacterized virus, was isolated in 1993 from Anopheles annulipes mosquitoes collected in the Kimberley region of northern Western Australia. Here, we report its genomic sequence, identify it as a rhabdovirus, and characterize its phylogenetic relationships. The genome comprises a P' (C) and SH protein similar to the recently characterized Tupaia and Durham viruses, and shows overlap between G and L genes. Comparison of K13965 genome sequence to other rhabdoviruses identified K13965 as a strain of the unclassified Australian Oak Vale rhabdovirus, whose complete genome sequence we also determined. Phylogenetic analysis of N and L sequences indicated genetic relationship to a recently proposed Sandjima virus clade, although the Oak Vale virus sequences form a branch separate from the African members of that group.

摘要

1993 年,在澳大利亚西北部金伯利地区采集的按蚊中分离到一种未被描述的病毒 K13965。在此,我们报告了其基因组序列,鉴定它为一种弹状病毒,并对其系统发育关系进行了特征描述。基因组包括一个与最近被描述的食蟹猴和达勒姆病毒相似的 P'(C)和 SH 蛋白,并显示 G 和 L 基因之间存在重叠。将 K13965 基因组序列与其他弹状病毒进行比较,将其鉴定为未分类的澳大利亚橡树谷弹状病毒的一个株系,我们还确定了其完整基因组序列。N 和 L 序列的系统发育分析表明,与最近提出的沙吉玛病毒群具有遗传关系,尽管橡树谷病毒序列与该组非洲成员形成一个分支。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baaa/3174045/8360f68a99a8/nihms316572f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baaa/3174045/7047d554db6e/nihms316572f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baaa/3174045/c23b21ca0c7a/nihms316572f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baaa/3174045/8360f68a99a8/nihms316572f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baaa/3174045/7047d554db6e/nihms316572f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baaa/3174045/c23b21ca0c7a/nihms316572f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baaa/3174045/8360f68a99a8/nihms316572f3.jpg

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