首个高分辨率DNA“甲基化组”。

The first high-resolution DNA "methylome".

作者信息

Schöb Hanspeter, Grossniklaus Ueli

机构信息

Institute of Plant Biology and Zürich-Basel Plant Science Center, University of Zürich, Zollikerstrasse 107, CH-8008 Zürich, Switzerland.

出版信息

Cell. 2006 Sep 22;126(6):1025-8. doi: 10.1016/j.cell.2006.09.002.

DOI:10.1016/j.cell.2006.09.002

PMID:16990127

Abstract

Cytosine methylation plays a crucial role in the regulation of gene expression and the control of genome stability in higher eukaryotes. Despite its importance for normal development, the degree and genome-wide distribution of DNA methylation has remained largely unknown. In this issue of Cell, fill this gap by presenting a high-resolution map of DNA methylation in the genome of the flowering plant Arabidopsis.

摘要

胞嘧啶甲基化在高等真核生物的基因表达调控和基因组稳定性控制中起着至关重要的作用。尽管其对正常发育很重要，但DNA甲基化的程度和全基因组分布在很大程度上仍不清楚。在本期《细胞》杂志中，通过展示开花植物拟南芥基因组中DNA甲基化的高分辨率图谱填补了这一空白。