Shin Ji Hoon, Song Ho-Young, Moon Dae Hyuk, Oh Seung-Jun, Kim Tae-Hyung, Lim Jin-Oh
Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, 388-1, Pungnap-2dong, Songpa-gu, Seoul 138-736, Korea.
J Vasc Interv Radiol. 2006 Sep;17(9):1471-7. doi: 10.1097/01.RVI.0000235738.28095.04.
To evaluate the efficacy of beta-irradiation therapy with use of a rhenium-188 mercaptoacetyltriglycine ((188)Re-MAG(3))-filled balloon for the prevention of restenosis in urethral strictures refractory to repetitive surgical or interventional procedures.
Five male patients with traumatic (n = 4) or postoperative anastomotic (n = 1) recurrent urethral strictures were included. One to four sessions of 20-30 Gy beta-irradiation at a 1-mm tissue depth with (188)Re-MAG(3)-filled balloon dilation were undertaken in each patient.
No procedural complications or toxicities were noted. During the mean follow-up period of 16.2 months, the stricture did not recur in two patients, whereas three patients required additional interventional procedures. In two of these patients, the treatment intervals between the required sessions were significantly prolonged. For the entire group, the mean treatment interval was prolonged from 2.2 months before (188)Re-MAG(3)-filled balloon dilation to 10.7 months after therapy.
(188)Re-MAG(3)-filled balloon dilation shows promise in preventing or delaying stricture recurrence in patients with recurrent urethral strictures.
评估使用填充铼 - 188巯基乙酰三甘氨酸（（188）Re - MAG（3））的球囊进行β射线照射治疗，预防对重复手术或介入治疗无效的尿道狭窄再狭窄的疗效。
纳入5例男性患者，其中4例为创伤性复发性尿道狭窄，1例为术后吻合口复发性尿道狭窄。对每位患者进行1至4次使用填充（188）Re - MAG（3）球囊扩张的β射线照射，组织深度为1毫米，剂量为20 - 30 Gy。
未观察到手术并发症或毒性反应。在平均16.2个月的随访期内，2例患者狭窄未复发，而3例患者需要额外的介入治疗。其中2例患者所需治疗间隔显著延长。对于整个组，平均治疗间隔从填充（188）Re - MAG（3）球囊扩张前的2.2个月延长至治疗后的10.7个月。
填充（188）Re - MAG（3）的球囊扩张在预防或延迟复发性尿道狭窄患者的狭窄复发方面显示出前景。
