Gilbert Fiona J, Astley Susan M, McGee Magnus A, Gillan Maureen G C, Boggis Caroline R M, Griffiths Pamela M, Duffy Stephen W
Department of Radiology, University of Aberdeen, Lilian Sutton Bldg, Foresterhill, Aberdeen, Scotland.
Radiology. 2006 Oct;241(1):47-53. doi: 10.1148/radiol.2411051092.
To retrospectively determine if the use of a computer-aided detection (CAD) system can improve the performance of single reading of screening mammograms to match that of double reading in the United Kingdom.
Local research ethics committee approval was obtained; informed consent was not required. This study included a sample of 10 267 mammograms obtained in women aged 50 years or older who underwent routine screening at one of two breast screening centers in 1996. Mammograms that were double read in 1996 were randomly allocated to be re-read by eight different radiologists using CAD. The cancer detection and recall rates from double reading and single reading with CAD were compared. Statistical significance and confidence intervals were calculated with the McNemar test to account for the matched nature of the data.
Single reading with CAD led to a cancer detection rate that was significantly (P = .02) higher than that achieved with double reading: 6.5% more cancers were detected by means of single reading with CAD than by means of double reading. However, the recall rate was higher for single reading with CAD than for double reading (8.6% vs 6.5%, respectively; P < .001). This was equivalent to relative increases of 15% and 32% in the cancer detection and recall rates, respectively.
Single reading with CAD leads to an improved cancer detection rate and an increased recall rate.
回顾性确定在英国使用计算机辅助检测（CAD）系统能否提高乳腺筛查钼靶单次阅片的性能，使其与双次阅片相匹配。
获得了当地研究伦理委员会的批准；无需知情同意。本研究纳入了1996年在两个乳腺筛查中心之一接受常规筛查的50岁及以上女性的10267例钼靶检查样本。1996年进行双次阅片的钼靶检查被随机分配给8位不同的放射科医生使用CAD重新阅片。比较了双次阅片和使用CAD单次阅片的癌症检出率和召回率。采用McNemar检验计算统计显著性和置信区间，以考虑数据的匹配性质。
使用CAD单次阅片的癌症检出率显著高于双次阅片（P = 0.02）：使用CAD单次阅片比双次阅片多检出6.5%的癌症。然而，使用CAD单次阅片的召回率高于双次阅片（分别为8.6%和6.5%；P < 0.001）。这相当于癌症检出率和召回率分别相对提高了15%和32%。
使用CAD单次阅片可提高癌症检出率并增加召回率。
