Kreuter M, Woelke K, Bieker R, Schliemann C, Steins M, Buechner T, Berdel W E, Mesters R M
Department of Medicine/Hematology and Oncology, University of Muenster, Muenster, Germany.
Leukemia. 2006 Nov;20(11):1950-4. doi: 10.1038/sj.leu.2404384. Epub 2006 Aug 31.
Neuropilin-1 (NRP-1), a vascular endothelial growth factors and semaphorin receptor functioning as mediator of angiogenesis and neuronal guidance, is expressed by various solid tumors. The importance of NRP-1 in hematological malignancies such as acute myeloid leukemia (AML) remains to be elucidated. Therefore, we determined NRP-1 expression by immunohistochemical analysis of bone marrow biopsies of patients with newly diagnosed, untreated AML. The expression of NRP-1 was significantly increased in AML patients (n = 76; median 12.9 arbitrary units (a.u.)) as compared with controls (n = 38; median 2.75 a.u.). Survival was significantly poorer in patients with high (> median) versus low (< or = median) NRP-1 expression levels with 5-year overall survival rates of 16.9 versus 49.6% (P = 0.050). In conclusion, our data provide evidence of increased NRP-1 expression in AML with significant correlation to survival. Thus, NRP-1 might constitute a promising target for antileukemic and antiangiogenic treatment strategies in AML.
神经纤毛蛋白-1（NRP-1）是一种血管内皮生长因子和信号素受体，在血管生成和神经元导向过程中起介导作用，多种实体瘤均可表达。NRP-1在急性髓系白血病（AML）等血液系统恶性肿瘤中的重要性尚待阐明。因此，我们通过对新诊断、未治疗的AML患者骨髓活检进行免疫组化分析来确定NRP-1的表达情况。与对照组（n = 38；中位数为2.75任意单位（a.u.））相比，AML患者（n = 76；中位数为12.9 a.u.）中NRP-1的表达显著增加。NRP-1表达水平高（>中位数）的患者与低（≤中位数）表达水平的患者相比，生存率明显更低，5年总生存率分别为16.9%和49.6%（P = 0.050）。总之，我们的数据证明AML中NRP-1表达增加，且与生存率显著相关。因此，NRP-1可能是AML抗白血病和抗血管生成治疗策略的一个有前景的靶点。
