COPII衣被：囊泡衣被组装的统一原则

The COPII cage: unifying principles of vesicle coat assembly.

作者信息

Gürkan Cemal, Stagg Scott M, Lapointe Paul, Balch William E

机构信息

Department of Electron Microscopy and Molecular Pathology, the Cyprus Institute of Neurology and Genetics, International Airport Avenue #6, Agios Dometios, 1683, Nicosia, Cyprus.

出版信息

Nat Rev Mol Cell Biol. 2006 Oct;7(10):727-38. doi: 10.1038/nrm2025.

DOI:10.1038/nrm2025

PMID:16990852

Abstract

Communication between compartments of the exocytic and endocytic pathways in eukaryotic cells involves transport carriers - vesicles and tubules - that mediate the vectorial movement of cargo. Recent studies of transport-carrier formation in the early secretory pathway have provided new insights into the mechanisms of cargo selection by coat protein complex-II (COPII) adaptor proteins, the construction of cage-protein scaffolds and fission. These studies are beginning to produce a unifying molecular and structural model of coat function in the formation and fission of vesicles and tubules in endomembrane traffic.

摘要

真核细胞中胞吐和胞吞途径各区室之间的通讯涉及运输载体——囊泡和小管——它们介导货物的定向运输。近期对早期分泌途径中运输载体形成的研究，为II型被膜小泡蛋白复合体（COPII）衔接蛋白选择货物的机制、笼形蛋白支架的构建及裂变提供了新见解。这些研究开始形成一个关于内膜运输中囊泡和小管形成及裂变过程中被膜功能的统一分子和结构模型。