雷帕霉素的生物合成：基因产物功能的阐明
Rapamycin biosynthesis: Elucidation of gene product function.
作者信息
Gregory Matthew A, Hong Hui, Lill Rachel E, Gaisser Sabine, Petkovic Hrvoje, Low Lindsey, Sheehan Lesley S, Carletti Isabelle, Ready Sarah J, Ward Michael J, Kaja Andrew L, Weston Alison J, Challis Iain R, Leadlay Peter F, Martin Christine J, Wilkinson Barrie, Sheridan Rose M
机构信息
Biotica, Chesterford Research Park, Little Chesterford, UK CB10 1XL.
出版信息
Org Biomol Chem. 2006 Oct 7;4(19):3565-8. doi: 10.1039/b608813a. Epub 2006 Aug 22.
DOI:10.1039/b608813a
PMID:16990929
Abstract
The function of gene products involved in the biosynthesis of the clinically important polyketide rapamycin were elucidated by biotransformation and gene complementation.
摘要
通过生物转化和基因互补阐明了参与临床重要聚酮化合物雷帕霉素生物合成的基因产物的功能。
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