• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Chemical synthesis of picornaviral protein primers of RNA replication.

作者信息

Kriek Nicole M A J, Meeuwenoord Nico J, van den Elst Hans, Heus Hans A, van der Marel Gijsbert A, Filippov Dmitri V

机构信息

Leiden Institute of Chemistry, Leiden University, PO Box 9502, 2300, RA Leiden, The Netherlands.

出版信息

Org Biomol Chem. 2006 Oct 7;4(19):3576-86. doi: 10.1039/b608544j. Epub 2006 Aug 30.

DOI:10.1039/b608544j
PMID:16990933
Abstract

Naturally occurring nucleopeptidic replication primers (VPg-pUpU) of poliovirus and coxsackie virus were chemically synthesized. The synthesis was accomplished via block-coupling of two minimally protected fragments of the target structures: a short RNA-nucleopeptide and a longer peptide segment containing diverse side-chain functionalities. The synthetic VPg-pUpU of coxsackie virus was characterized by NMR spectroscopy.

摘要

相似文献

1
Chemical synthesis of picornaviral protein primers of RNA replication.
Org Biomol Chem. 2006 Oct 7;4(19):3576-86. doi: 10.1039/b608544j. Epub 2006 Aug 30.
2
The structure-function relationship of the enterovirus 3'-UTR.肠道病毒3'-非翻译区的结构-功能关系
Virus Res. 2009 Feb;139(2):209-16. doi: 10.1016/j.virusres.2008.07.014. Epub 2008 Aug 30.
3
Solid-phase synthesis of an RNA nucleopeptide fragment from the nucleoprotein of poliovirus.脊髓灰质炎病毒核蛋白RNA核肽片段的固相合成。
Nucleic Acids Res. 1992 May 25;20(10):2435-9. doi: 10.1093/nar/20.10.2435.
4
Tyrosine 3 of poliovirus terminal peptide VPg(3B) has an essential function in RNA replication in the context of its precursor protein, 3AB.脊髓灰质炎病毒末端肽VPg(3B)的酪氨酸3在其前体蛋白3AB的背景下对RNA复制具有重要功能。
J Virol. 2007 Jun;81(11):5669-84. doi: 10.1128/JVI.02350-06. Epub 2007 Mar 14.
5
Amiloride inhibits the initiation of Coxsackievirus and poliovirus RNA replication by inhibiting VPg uridylylation.阿米洛利通过抑制 VPg 尿苷酸化来抑制柯萨奇病毒和脊髓灰质炎病毒 RNA 的复制。
Virology. 2014 Sep;464-465:87-97. doi: 10.1016/j.virol.2014.06.025. Epub 2014 Jul 22.
6
Fully automated sequential solid phase approach towards viral RNA-nucleopeptides.全自动顺序固相法制备病毒 RNA-核肽。
Chem Commun (Camb). 2012 Aug 21;48(65):8093-5. doi: 10.1039/c2cc33477a. Epub 2012 Jul 10.
7
Nucleotide channel of RNA-dependent RNA polymerase used for intermolecular uridylylation of protein primer.用于蛋白质引物分子间尿苷酸化的RNA依赖性RNA聚合酶的核苷酸通道。
J Mol Biol. 2006 Mar 24;357(2):665-75. doi: 10.1016/j.jmb.2005.12.044. Epub 2006 Jan 5.
8
Live cell imaging of protein interactions in poliovirus RNA replication complex using fluorescence resonance energy transfer (FRET).利用荧光共振能量转移（FRET）对脊髓灰质炎病毒RNA复制复合体中的蛋白质相互作用进行活细胞成像。
Biochem Biophys Res Commun. 2008 Apr 11;368(3):489-94. doi: 10.1016/j.bbrc.2008.01.094. Epub 2008 Feb 4.
9
Relationship between poliovirus negative-strand RNA synthesis and the length of the 3' poly(A) tail.脊髓灰质炎病毒负链RNA合成与3'多聚腺苷酸尾长度之间的关系
Virology. 2006 Feb 20;345(2):509-19. doi: 10.1016/j.virol.2005.10.019. Epub 2005 Nov 16.
10
Initiation of poliovirus plus-strand RNA synthesis in a membrane complex of infected HeLa cells.脊髓灰质炎病毒正链RNA在受感染的HeLa细胞膜复合物中的合成起始
J Virol. 1986 Oct;60(1):43-53. doi: 10.1128/JVI.60.1.43-53.1986.

引用本文的文献

1
Solid Phase Synthesis and TAR RNA-Binding Activity of Nucleopeptides Containing Nucleobases Linked to the Side Chains via 1,4-Linked-1,2,3-triazole.通过1,4-连接的1,2,3-三唑将核碱基连接到侧链的核肽的固相合成及TAR RNA结合活性
Biomedicines. 2024 Mar 3;12(3):570. doi: 10.3390/biomedicines12030570.
2
Artificial bioconjugates with naturally occurring linkages: the use of phosphodiester.具有天然连接键的人工生物共轭物：磷酸二酯的应用。
Beilstein J Org Chem. 2018 Jul 27;14:1946-1955. doi: 10.3762/bjoc.14.169. eCollection 2018.