Chemical synthesis of picornaviral protein primers of RNA replication.
作者信息
Kriek Nicole M A J, Meeuwenoord Nico J, van den Elst Hans, Heus Hans A, van der Marel Gijsbert A, Filippov Dmitri V
机构信息
Leiden Institute of Chemistry, Leiden University, PO Box 9502, 2300, RA Leiden, The Netherlands.
出版信息
Org Biomol Chem. 2006 Oct 7;4(19):3576-86. doi: 10.1039/b608544j. Epub 2006 Aug 30.
DOI:10.1039/b608544j
PMID:16990933
Abstract
Naturally occurring nucleopeptidic replication primers (VPg-pUpU) of poliovirus and coxsackie virus were chemically synthesized. The synthesis was accomplished via block-coupling of two minimally protected fragments of the target structures: a short RNA-nucleopeptide and a longer peptide segment containing diverse side-chain functionalities. The synthetic VPg-pUpU of coxsackie virus was characterized by NMR spectroscopy.
摘要
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