Dreef-Tromp C M, van den Elst H, van den Boogaart J E, van der Marel G A, van Boom J H
Gorlaeus Laboratory, Leiden, The Netherlands.
Nucleic Acids Res. 1992 May 25;20(10):2435-9. doi: 10.1093/nar/20.10.2435.
The naturally occurring RNA-nucleopeptide H-Ala-Tyr[5'-pUUAAAAC-3']-NH2 is prepared via a solid-phase phosphite triester approach using N-SiOMB/O-TBDMS-protected nucleosides. Preliminary 1H-NMR studies show that the peptidyl unit has a remarkable effect on the conformational behaviour of the RNA moiety in the nucleopeptide.
天然存在的RNA-核肽H-Ala-Tyr[5'-pUUAAAAC-3']-NH2是通过使用N-SiOMB/O-TBDMS保护的核苷的固相亚磷酸三酯方法制备的。初步的1H-NMR研究表明，肽基单元对核肽中RNA部分的构象行为有显著影响。
