Kannappan S, Jayaraman T, Rajasekar P, Ravichandran M K, Anuradha C V
Department of Biochemistry, Annamalai University, Annamalai Nagar, Tamil Nadu 608002, India.
Singapore Med J. 2006 Oct;47(10):858-63.
The present study was designed to investigate whether cinnamon bark extract (CBEt) mitigates the adverse effects of fructose loading on glucose metabolism and lipid profile in rats.
Adult male albino rats of body weight 150-170 g were divided into five groups and fed with either control or high fructose diet (HFD). CBEt was administered to HFD-fed rats orally at two doses (a low and a high dose) while the control diet-fed rats were treated with a high dose of CBEt. The treatment protocol was carried out for 60 days after which the oral glucose tolerance test was carried out. Biochemical parameters related to glucose metabolism and lipid profile were assayed.
The levels of glucose, insulin and protein-bound sugars were higher and activities of enzymes of glucose metabolism were altered in HFD-fed rats, as compared to control animals. The levels were brought back to near-normal when administered with CBEt at high dose. CBEt also prevented the hyperlipidaemia observed in fructose-fed rats and improved glucose tolerance. CBEt did not show any significant effect in fructose-fed rats when administered at low dose.
These findings indicate the improvement of glucose metabolism in-vivo by CBEt in fructose-fed rats.
本研究旨在调查肉桂树皮提取物（CBEt）是否能减轻果糖负荷对大鼠葡萄糖代谢和血脂水平的不良影响。
将体重150 - 170克的成年雄性白化大鼠分为五组，分别给予对照饮食或高果糖饮食（HFD）。以两种剂量（低剂量和高剂量）对喂食HFD的大鼠口服给予CBEt，而对喂食对照饮食的大鼠给予高剂量的CBEt。治疗方案持续60天，之后进行口服葡萄糖耐量试验。检测与葡萄糖代谢和血脂水平相关的生化参数。
与对照动物相比，喂食HFD的大鼠血糖、胰岛素和蛋白结合糖水平更高，葡萄糖代谢酶活性发生改变。高剂量给予CBEt时，这些水平恢复到接近正常。CBEt还可预防果糖喂养大鼠出现的高脂血症，并改善葡萄糖耐量。低剂量给予CBEt时，对果糖喂养大鼠未显示出任何显著影响。
这些发现表明CBEt可在体内改善果糖喂养大鼠的葡萄糖代谢。
