Alsoodeeri Fahadah Naeef, Alqabbani Hissah Mohammed, Aldossari Norah Mubarak
Department of Home Economics, College of Home Economics, King Khalid University, Abha, Saudi Arabia.
Department of Home Economics, College of Education-Dilam, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia.
J Lipids. 2020 Jan 23;2020:8469830. doi: 10.1155/2020/8469830. eCollection 2020.
Dyslipidemia is an important cause of cardiovascular diseases (CVDs), which are the most prevalent causes of morbidity and mortality. The purpose of this study was to assess the effects of cinnamon on body weight gain, food intake, and serum lipid profiles of albino rats. This study was conducted on 30 healthy male albino rats weighing approximately 130 ± 5 g. The study was divided into the following two experiments: experiment (1), wherein rats were fed a laboratory diet; and experiment (2), wherein rats were fed a high-fat diet. In experiment 1, a total of 15 rats were divided into three groups. Group A ( = 5, untreated control) was fed laboratory diet, Group B ( = 5) was fed laboratory diet and cinnamon powder (2 g/kg body weight), and Group C ( = 5) was fed laboratory diet and cinnamon powder (4 g/kg body weight) for 30 days. In experiment (2), a total of 15 rats were similarly divided into three groups. Group D ( = 5, treated control) was fed laboratory diet plus high-fat diet, Group E ( = 5) was fed cinnamon powder (2 g/kg body weight) mixed with laboratory diet plus high-fat diet, and Group F ( = 5) was fed cinnamon powder (4 g/kg body weight) mixed with laboratory diet plus high-fat diet daily for 30 days. An administration of 4 g/kg body weight of cinnamon extract powder decreased the final weight by 4.4%, body weight gains by 31.41%, food intake by 1.7%, and food efficiency ratio by 22.38% in hypercholesterolemic adult male rats as well as serum total cholesterol by 31.22%, triglyceride by 24.05%, and LDL-C by 43.49%, with an increase in the levels of HDL-C by 30.16%, furthermore, a significant decrease in serum total cholesterol, triglycerides, and LDL-C levels and increasing serum HDL-C on day 30 were observed ( < 0.001). This finding provides scientific evidence to substantiate the traditional use of cinnamon to treat hyperlipidemia.
血脂异常是心血管疾病（CVDs）的一个重要病因，而心血管疾病是发病和死亡的最常见原因。本研究的目的是评估肉桂对白化大鼠体重增加、食物摄入量和血清脂质谱的影响。本研究以30只体重约130±5克的健康雄性白化大鼠为对象。研究分为以下两个实验：实验（1），大鼠喂食实验室日粮；实验（2），大鼠喂食高脂日粮。在实验1中，总共15只大鼠分为三组。A组（n = 5，未处理对照）喂食实验室日粮，B组（n = 5）喂食实验室日粮和肉桂粉（2克/千克体重），C组（n = 5）喂食实验室日粮和肉桂粉（4克/千克体重），持续30天。在实验（2）中，总共15只大鼠同样分为三组。D组（n = 5，处理对照）喂食实验室日粮加高脂日粮，E组（n = 5）喂食与实验室日粮加高脂日粮混合的肉桂粉（2克/千克体重），F组（n = 5）喂食与实验室日粮加高脂日粮混合的肉桂粉（4克/千克体重），每天持续30天。在高胆固醇血症成年雄性大鼠中，给予4克/千克体重的肉桂提取物粉末可使最终体重降低4.4%，体重增加降低31.41%，食物摄入量降低1.7%，食物效率比降低22.38%，血清总胆固醇降低31.22%，甘油三酯降低24.05%，低密度脂蛋白胆固醇降低43.49%，高密度脂蛋白胆固醇水平升高30.16%，此外，在第30天时观察到血清总胆固醇、甘油三酯和低密度脂蛋白胆固醇水平显著降低，血清高密度脂蛋白胆固醇升高（P < 0.001）。这一发现为证实肉桂治疗高脂血症的传统用途提供了科学依据。
