Mendelson W B, Reichman J, Othmer E
Biol Psychiatry. 1975 Aug;10(4):459-64.
Methysergide a clinically used blocker of serotonin receptors, was given for 48 hr to 11 normal adults, at a dose of 8 mg per 24 hr. Total REM sleep time was decreased, although total sleep time was unchanged. Stage 4 decreased and stage 3 increased, while total slow wave sleep remained constant. There was a tendency toward a decrease in the number of intact sleep cycles. The relationship of these data to published reports on p-chlorophenylalanine is discussed.
美西麦角是一种临床使用的血清素受体阻滞剂，以每24小时8毫克的剂量给予11名正常成年人，持续48小时。尽管总睡眠时间没有变化，但快速眼动睡眠总时间减少了。4期睡眠减少，3期睡眠增加，而慢波睡眠总量保持不变。完整睡眠周期的数量有减少的趋势。本文讨论了这些数据与已发表的关于对氯苯丙氨酸的报告之间的关系。
