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盐负荷和血液稀释对灌注猫肾血管紧张素反应的影响。

Effects of salt loading and haemodilution on the responses of perfused cat kidneys to angiotensin.

作者信息

Lockett M F

出版信息

J Physiol. 1967 Dec;193(3):639-47. doi: 10.1113/jphysiol.1967.sp008384.

DOI:10.1113/jphysiol.1967.sp008384
PMID:16992302
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1365519/
Abstract
  1. Effects of single intra-arterial injections (0.1-1.0 mug) of angiotensin II have been observed on cat kidneys perfused with heparinized blood from heart-lung circuits.2. Angiotensin II always caused an abrupt decrease in renal plasma flow (R.P.F.) which reached maximum in 1-2 min and lasted over-all for only 3.5-4.0 min. Glomerular filtration rate (G.F.R.) usually and filtration fraction (F.F.) always increased.3. Angiotensin II caused antidiuresis provided that the kidney had not been subjected either to salt loading or to haemodilution within the preceding 3 hr. These pretreatments converted the antidiuretic action of angiotensin into a diuresis.4. Angiotensin II raised the rate of Na excretion, the urinary concentration of Na and the urinary Na/K whether anti-diuretic or diuretic.
摘要

  1. 观察了经心肺循环用肝素化血液灌注的猫肾，单次动脉内注射（0.1 - 1.0微克）血管紧张素II的作用。

  2. 血管紧张素II总是导致肾血浆流量（R.P.F.）突然下降，在1 - 2分钟内达到最大值，总体持续仅3.5 - 4.0分钟。肾小球滤过率（G.F.R.）通常增加，滤过分数（F.F.）总是增加。

  3. 如果在之前3小时内肾脏未进行盐负荷或血液稀释处理，血管紧张素II会引起抗利尿作用。这些预处理会将血管紧张素的抗利尿作用转变为利尿作用。

  4. 无论产生抗利尿还是利尿作用，血管紧张素II都会提高钠排泄率、尿钠浓度和尿钠/钾比值。

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引用本文的文献

1
Renal actions of dihydroergocristine and of phentolamine in anaesthetized cats.双氢麦角汀和酚妥拉明对麻醉猫的肾脏作用。
Br J Pharmacol. 1969 Nov;37(3):595-608. doi: 10.1111/j.1476-5381.1969.tb08498.x.
2
The separation of renal activity from lung and from the venous effluent from perfused lungs.肾脏活动与肺部以及灌注肺静脉流出物的分离。
J Physiol. 1971 Feb;212(3):719-31. doi: 10.1113/jphysiol.1971.sp009352.

本文引用的文献

1
Hypotensive agents and pressor substances. The effect of epinephrine, norepinephrine, angiotensin II, and others on the secretory rate of aldosterone in man.降压药和升压物质。肾上腺素、去甲肾上腺素、血管紧张素II等对人体醛固酮分泌率的影响。
JAMA. 1960 Sep 17;174:234-40. doi: 10.1001/jama.1960.03030030014003.
2
THE RENIN-ANGIOTENSIN SYSTEM.肾素-血管紧张素系统
Pharmacol Rev. 1965 Jun;17:143-82.
3
THE IN VIVO EFFECT OF ANGIOTENSIN ON THE PROXIMAL TUBULAR REABSORPTION OF SALT IN RAT KIDNEYS.血管紧张素对大鼠肾脏近端小管盐重吸收的体内作用
Acta Physiol Scand. 1964 Dec;62:436-48. doi: 10.1111/j.1748-1716.1964.tb10441.x.
4
VARIATIONS IN PLASMA RENIN CONCENTRATION IN SEVERAL PHYSIOLOGICAL AND PATHOLOGICAL STATES.几种生理和病理状态下血浆肾素浓度的变化
Can Med Assoc J. 1964 Jan 25;90(4):201-6.
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Inhibition of distal tubular sodium reabsorption by angiotensin. II.血管紧张素对远曲小管钠重吸收的抑制作用。II.
Am J Physiol. 1963 Jul;205:133-8. doi: 10.1152/ajplegacy.1963.205.1.133.
6
Actions and interactions of aldosterone monoacetate and neurohypophysial hormones on the isolated cat kidney.单醋酸醛固酮与神经垂体激素对离体猫肾的作用及相互作用
J Physiol. 1960 Jul;152(2):206-19. doi: 10.1113/jphysiol.1960.sp006482.
7
Inhibition of sodium transport in isolated renal tissue by angiotensin.
Biochim Biophys Acta. 1961 Apr 15;48:602-3. doi: 10.1016/0006-3002(61)90063-4.
8
Evaluation of the pressor, cardiac, and renal hemodynamic properties of angiotensin II in man.对人体中血管紧张素II的升压、心脏及肾脏血液动力学特性的评估。
Circ Res. 1961 Mar;9:256-63. doi: 10.1161/01.res.9.2.256.
9
A comparison of the circulatory effects of angiotensin, vasopressin and adrenaline in the anaesthetized cat.麻醉猫体内血管紧张素、血管加压素和肾上腺素对循环系统作用的比较。
J Physiol. 1961 Apr;156(1):49-66. doi: 10.1113/jphysiol.1961.sp006657.
10
[Effect of synthetic hypertensin II on PAH- and inulin clearance, on renal hemodynamics and on diuresis in man].[合成血管紧张素II对人体中PAH和菊粉清除率、肾血流动力学及利尿作用的影响]
Klin Wochenschr. 1958 Jan 15;36(2):69-74. doi: 10.1007/BF01486247.