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The separation of renal activity from lung and from the venous effluent from perfused lungs.肾脏活动与肺部以及灌注肺静脉流出物的分离。
J Physiol. 1971 Feb;212(3):719-31. doi: 10.1113/jphysiol.1971.sp009352.
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引用本文的文献

1
The formation of a renally active peptide by cat lungs from gamma-globulin in vitro and the plasma concentrations of this peptide, in vivo.猫肺在体外由γ球蛋白形成具有肾脏活性的肽以及该肽在体内的血浆浓度。
J Physiol. 1972 Jul;224(1):187-94. doi: 10.1113/jphysiol.1972.sp009888.

本文引用的文献

1
Hormonal actions of the heart and of lungs on the isolated kidney.心脏和肺对离体肾脏的激素作用。
J Physiol. 1967 Dec;193(3):661-9. doi: 10.1113/jphysiol.1967.sp008386.
2
Effects of salt loading and haemodilution on the responses of perfused cat kidneys to angiotensin.盐负荷和血液稀释对灌注猫肾血管紧张素反应的影响。
J Physiol. 1967 Dec;193(3):639-47. doi: 10.1113/jphysiol.1967.sp008384.
3
THE RENIN-ANGIOTENSIN SYSTEM.肾素-血管紧张素系统
Pharmacol Rev. 1965 Jun;17:143-82.
4
The technique of superfusion.超灌注技术。
Br J Pharmacol Chemother. 1953 Sep;8(3):321-6. doi: 10.1111/j.1476-5381.1953.tb00801.x.
5
Changes in the flow and composition of the urine induced by the 18 monoacetate of D-aldosterone, in cats.猫体内由D - 醛固酮18 - 单乙酸酯引起的尿液流量和成分变化。
J Physiol. 1969 Jun;202(3):671-82. doi: 10.1113/jphysiol.1969.sp008834.
6
Similarity between a substance produced by the heart in vitro and the 18-monoacetyl derivative of D-aldosterone.心脏体外产生的一种物质与D-醛固酮的18-单乙酰衍生物之间的相似性。
J Endocrinol. 1969 Feb;43(2):315-6. doi: 10.1677/joe.0.0430315.
7
A renally active substance from heart muscle and from blood.一种来自心肌和血液的具有肾脏活性的物质。
J Physiol. 1968 May;196(1):101-9. doi: 10.1113/jphysiol.1968.sp008497.
8
The release of a renally active substance by perfused rat hearts.灌注大鼠心脏释放一种具有肾脏活性的物质。
J Physiol. 1971 Feb;212(3):733-8. doi: 10.1113/jphysiol.1971.sp009353.
9
Factors controlling the secretion of a substance biologically resembling the 18-monoacetate of D-aldosterone by heart muscle.控制心肌分泌一种生物学上类似于D-醛固酮18-单乙酸酯物质的因素。
J Physiol. 1970 Oct;210(3):717-25. doi: 10.1113/jphysiol.1970.sp009237.
10
Release of oxytocin contributes to the natriuretic action of aminophylline in rats.催产素的释放有助于氨茶碱在大鼠体内的利钠作用。
J Pharm Pharmacol. 1968 Sep;20(9):688-96. doi: 10.1111/j.2042-7158.1968.tb09839.x.

肾脏活动与肺部以及灌注肺静脉流出物的分离。

The separation of renal activity from lung and from the venous effluent from perfused lungs.

作者信息

Lockett M F

出版信息

J Physiol. 1971 Feb;212(3):719-31. doi: 10.1113/jphysiol.1971.sp009352.

DOI:10.1113/jphysiol.1971.sp009352
PMID:4326690
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1395713/
Abstract
  1. Antidiuretic and salt-retaining activity has been separated from cat and ox lung, and from the venous effluent of blood-perfused cat lungs, by acetone extraction, gel filtration, partition and thin-layer chromatography.2. The chromatographic properties of the renally active substance from lung and from pulmonary venous blood are similar.3. The renal actions of these substances, demonstrable in vivo and in the isolated organ, are characterized by reduction in the excretion of water and Na. Renal blood flow, glomerular filtration rate and the urinary Na/K are not significantly affected.4. Concentrations of the lung substance which equate with angiotensin II-val(5)-amide in reduction of urinary Na in rats during water diuresis and under alcohol sedation do not raise the mean arterial pressure of the anaesthetized rat nor contract the superfused rat colon. At these dose levels angiotensin II is markedly vasopressor and contracts the superfused rat colon.
摘要

  1. 通过丙酮萃取、凝胶过滤、分配色谱和薄层色谱法，已从猫和牛的肺以及血液灌注猫肺的静脉流出物中分离出抗利尿和保盐活性物质。

  2. 来自肺和肺静脉血的具有肾活性物质的色谱特性相似。

  3. 这些物质在体内和离体器官中表现出的肾脏作用的特征是水和钠排泄减少。肾血流量、肾小球滤过率和尿钠/钾比值未受到显著影响。

  4. 在水利尿期间和酒精镇静作用下，与血管紧张素II-缬氨酸(5)-酰胺在减少大鼠尿钠方面等效的肺物质浓度，不会提高麻醉大鼠的平均动脉压，也不会使灌注的大鼠结肠收缩。在这些剂量水平下，血管紧张素II具有明显的升压作用，并使灌注的大鼠结肠收缩。