多巴胺诱导豚鼠颌下腺淀粉酶分泌
Dopamine-induced amylase secretion from guinea-pig submandibular gland.
作者信息
Bloom G D, Carlsöö B, Danielsson A
出版信息
Br J Pharmacol. 1975 Aug;54(4):523-8. doi: 10.1111/j.1476-5381.1975.tb07600.x.
Abstract
- The effects of dopamine, 5-hydroxydopamine (5-OHDA) and noradrenaline on amylase secretion from the guinea-pig submandibular gland were investigated under in vitro conditions. 2. All three amines greatly enhanced amylase secretion. Blockade of dopamine beta-hydroxylase did not inhibit the response to dopamine. 3. Noradrenaline and dopamine stimulated amylase release from salivary glands of reserpine-treated animals, whereas 5-OHDA had no stimulatory effect on secretion in guinea-pigs pretreated with reserpine. 4. Haloperidol completely inhibited dopamine-induced enzyme discharge, but did not affect noradrenaline-initiated secretion. 5. Apomorphine caused a slight enzyme release by itself; it diminished the dopamine secretory effect, but did not modify that of noradrenaline. 6. Pimozide and fluspirilene attenuated the dopamine-induced enzyme discharge, but compared with haloperidol they were less effective. 7. It is concluded that dopamine exerts a secretagogic action different from that of noradrenaline. The possible presence of a specific dopamine receptor in salivary glands is discussed.
摘要
- 在体外条件下研究了多巴胺、5-羟多巴胺（5-OHDA）和去甲肾上腺素对豚鼠下颌下腺淀粉酶分泌的影响。2. 这三种胺类均显著增强淀粉酶分泌。多巴胺β-羟化酶的阻断并不抑制对多巴胺的反应。3. 去甲肾上腺素和多巴胺刺激利血平处理动物唾液腺的淀粉酶释放，而5-OHDA对利血平预处理的豚鼠的分泌无刺激作用。4. 氟哌啶醇完全抑制多巴胺诱导的酶释放，但不影响去甲肾上腺素引发的分泌。5. 阿扑吗啡自身引起轻微的酶释放；它减弱多巴胺的分泌作用，但不改变去甲肾上腺素的分泌作用。6. 匹莫齐特和氟司必林减弱多巴胺诱导的酶释放，但与氟哌啶醇相比，它们的效果较差。7. 得出结论，多巴胺发挥的促分泌作用不同于去甲肾上腺素。讨论了唾液腺中可能存在特异性多巴胺受体的情况。
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