Carlsöö B, Danielsson A, Henriksson R, Idahl L A
Br J Pharmacol. 1981 Feb;72(2):271-6. doi: 10.1111/j.1476-5381.1981.tb09124.x.
1 The effects of various beta-adrenoceptor agonists on amylase secretion from the rat parotid gland were studied by means of two different in vitro techniques. 2 The dose-response relation for each agonist was established, as also were the ED50 values. 3 All drugs appeared to act directly on the acinar cells, as reserpine-treatment did not abolish their secretagogic effects. 4 Two groups of agonists could be distinguished: one group consisting of adrenaline, noradrenaline and the B1-selective agonist prenalterol (H133/22) with a high enzyme discharge potency and a second group consisting of the beta 2-agonists, terbutaline and salbutamol, with a markedly lower effect. 5 The present data further support the theory that rat parotid acinar cells are supplied mainly with beta-adrenoceptors of the beta 1-subtype, similar to those present in heart and adipose tissue.
采用两种不同的体外技术研究了各种β-肾上腺素能激动剂对大鼠腮腺淀粉酶分泌的影响。
确定了每种激动剂的剂量-反应关系以及半数有效剂量（ED50）值。
所有药物似乎都直接作用于腺泡细胞，因为利血平处理并未消除它们的促分泌作用。
可区分出两组激动剂：一组由肾上腺素、去甲肾上腺素和具有高酶释放效力的β1选择性激动剂普瑞特罗（H133/22）组成，另一组由β2激动剂特布他林和沙丁胺醇组成，其作用明显较低。
目前的数据进一步支持了这样一种理论，即大鼠腮腺腺泡细胞主要配备有β1亚型的β-肾上腺素能受体，类似于心脏和脂肪组织中存在的那些受体。
