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大鼠腮腺β-肾上腺素能受体的特性研究

Characterization of the rat parotid beta-adrenoceptor.

作者信息

Carlsöö B, Danielsson A, Henriksson R, Idahl L A

出版信息

Br J Pharmacol. 1981 Feb;72(2):271-6. doi: 10.1111/j.1476-5381.1981.tb09124.x.

DOI:10.1111/j.1476-5381.1981.tb09124.x
PMID:6163495
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2071516/
Abstract

1 The effects of various beta-adrenoceptor agonists on amylase secretion from the rat parotid gland were studied by means of two different in vitro techniques. 2 The dose-response relation for each agonist was established, as also were the ED50 values. 3 All drugs appeared to act directly on the acinar cells, as reserpine-treatment did not abolish their secretagogic effects. 4 Two groups of agonists could be distinguished: one group consisting of adrenaline, noradrenaline and the B1-selective agonist prenalterol (H133/22) with a high enzyme discharge potency and a second group consisting of the beta 2-agonists, terbutaline and salbutamol, with a markedly lower effect. 5 The present data further support the theory that rat parotid acinar cells are supplied mainly with beta-adrenoceptors of the beta 1-subtype, similar to those present in heart and adipose tissue.

摘要

  1. 采用两种不同的体外技术研究了各种β-肾上腺素能激动剂对大鼠腮腺淀粉酶分泌的影响。

  2. 确定了每种激动剂的剂量-反应关系以及半数有效剂量（ED50）值。

  3. 所有药物似乎都直接作用于腺泡细胞，因为利血平处理并未消除它们的促分泌作用。

  4. 可区分出两组激动剂：一组由肾上腺素、去甲肾上腺素和具有高酶释放效力的β1选择性激动剂普瑞特罗（H133/22）组成，另一组由β2激动剂特布他林和沙丁胺醇组成，其作用明显较低。

  5. 目前的数据进一步支持了这样一种理论，即大鼠腮腺腺泡细胞主要配备有β1亚型的β-肾上腺素能受体，类似于心脏和脂肪组织中存在的那些受体。

相似文献

1
Characterization of the rat parotid beta-adrenoceptor.大鼠腮腺β-肾上腺素能受体的特性研究
Br J Pharmacol. 1981 Feb;72(2):271-6. doi: 10.1111/j.1476-5381.1981.tb09124.x.
2
Effects of neonatal sympathetic denervation on amylase secretion in the adult rat parotid gland: difference in beta 1- and beta 2-adrenoceptor response.新生期交感神经去支配对成年大鼠腮腺淀粉酶分泌的影响：β1-和β2-肾上腺素能受体反应的差异
Eur J Pharmacol. 1982 Feb 26;78(2):195-200. doi: 10.1016/0014-2999(82)90236-9.
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Effects of a new selective beta1-adrenoceptor agonist on amylase secretion from the rat parotid gland.一种新型选择性β1肾上腺素能受体激动剂对大鼠腮腺淀粉酶分泌的影响。
Br J Pharmacol. 1978 Mar;62(3):364-6. doi: 10.1111/j.1476-5381.1978.tb08470.x.
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beta 1- and beta 2-adrenoceptor agonists have different effects on rat parotid acinar cells.β1和β2肾上腺素能受体激动剂对大鼠腮腺腺泡细胞有不同影响。
Am J Physiol. 1982 May;242(5):G481-5. doi: 10.1152/ajpgi.1982.242.5.G481.
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Acta Physiol Scand. 1984 Mar;120(3):429-35. doi: 10.1111/j.1748-1716.1984.tb07403.x.
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Dissociation of beta-adrenoceptor-induced effects on amylase secretion and cyclic adenosine 3', 5' monophosphate accumulation.β-肾上腺素能受体诱导的淀粉酶分泌和环磷酸腺苷积累效应的解离。
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Isoflurane--a study of its adrenoceptor interaction in the isolated rat parotid gland.异氟烷——对其在离体大鼠腮腺中肾上腺素能受体相互作用的研究。
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Jpn J Pharmacol. 1985 Feb;37(2):212-4. doi: 10.1254/jjp.37.212.
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Jpn J Pharmacol. 1985 Jan;37(1):129-32. doi: 10.1254/jjp.37.129.

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Dissociation of beta-adrenoceptor-induced effects on amylase secretion and cyclic adenosine 3', 5' monophosphate accumulation.β-肾上腺素能受体诱导的淀粉酶分泌和环磷酸腺苷积累效应的解离。
Br J Pharmacol. 1982 Apr;75(4):633-8. doi: 10.1111/j.1476-5381.1982.tb09184.x.
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Int J Pancreatol. 1988 May;3(4):293-300. doi: 10.1007/BF02788458.
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Dopamine actions in vitro on enzyme and electrolyte secretion from normal and sympathectomized rat parotid glands.多巴胺对正常及交感神经切除大鼠腮腺酶和电解质分泌的体外作用。
J Physiol. 1988 Oct;404:145-56. doi: 10.1113/jphysiol.1988.sp017283.
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Beta-adrenergic upregulation of the Na(+)-K(+)-2Cl- cotransporter in rat parotid acinar cells.大鼠腮腺腺泡细胞中Na(+)-K(+)-2Cl-共转运体的β-肾上腺素能上调
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Dynamics of beta adrenoceptor induced amylase release and cyclic AMP accumulation in the guinea pig submandibular gland.豚鼠颌下腺中β肾上腺素能受体诱导的淀粉酶释放及环磷酸腺苷积累的动力学
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