重温费伊和劳施1969年的研究：阿拉斯加小型哺乳动物体内的微小巴贝斯虫。

Fay and Rausch 1969 revisited: Babesia microti in Alaskan small mammals.

作者信息

Goethert Heidi K, Cook Joseph A, Lance Ellen Weintraub, Telford Sam R

机构信息

Division of Infectious Diseases, Cummings School of Veterinary Medicine, Tufts University, North Grafton, Massachusetts 01536, USA.

出版信息

J Parasitol. 2006 Aug;92(4):826-31. doi: 10.1645/GE-584R.1.

DOI:10.1645/GE-584R.1

PMID:16995402

Abstract

The Holarctic distribution of Babesia microti within small rodents implies an ancient association. A seminal report of piroplasms in Alaskan voles suggested to us the possibility that B. microti entered North America within Eurasian microtine rodents dispersing through Beringian corridors. To test this hypothesis, we analyzed samples from Alaskan rodents by polymerase chain reaction for evidence of infection with B. microti; one-third of the rodents were found to be infected. Sequence analysis of the 18S rDNA gene demonstrates that Alaskan B. microti comprises a clade that infects microtines in several sites across North America and is distinct from a clade that is zoonotic.

摘要

微小巴贝斯虫在小型啮齿动物中的全北区分布意味着一种古老的关联。一份关于阿拉斯加田鼠梨形虫的开创性报告让我们想到，微小巴贝斯虫可能是随着欧亚田鼠类啮齿动物通过白令陆桥走廊扩散而进入北美的。为了验证这一假设，我们通过聚合酶链反应分析了阿拉斯加啮齿动物的样本，以寻找感染微小巴贝斯虫的证据；结果发现三分之一的啮齿动物受到了感染。对18S rDNA基因的序列分析表明，阿拉斯加的微小巴贝斯虫构成一个分支，该分支感染北美多个地区的田鼠类，并且与一个人畜共患的分支不同。