Schrauzer G N, Shrestha K P
Department of Chemistry and Biochemistry, University of California at San Diego, Revelle College, La Jolla 92093.
Biol Trace Elem Res. 1990 May;25(2):105-13. doi: 10.1007/BF02990271.
Using data for 27 Texas counties from 1978-1987, it is shown that the incidence rates of suicide, homicide, and rape are significantly higher in counties whose drinking water supplies contain little or no lithium than in counties with water lithium levels ranging from 70-170 micrograms/L; the differences remain statistically significant (p less than 0.01) after corrections for population density. The corresponding associations with the incidence rates of robbery, burglary, and theft were statistically significant with p less than 0.05. These results suggest that lithium has moderating effects on suicidal and violent criminal behavior at levels that may be encountered in municipal water supplies. Comparisons of drinking water lithium levels, in the respective Texas counties, with the incidences of arrests for possession of opium, cocaine, and their derivatives (morphine, heroin, and codeine) from 1981-1986 also produced statistically significant inverse associations, whereas no significant or consistent associations were observed with the reported arrest rates for possession of marijuana, driving under the influence of alcohol, and drunkenness. These results suggest that lithium at low dosage levels has a generally beneficial effect on human behavior, which may be associated with the functions of lithium as a nutritionally-essential trace element. Subject to confirmation by controlled experiments with high-risk populations, increasing the human lithium intakes by supplementation, or the lithiation of drinking water is suggested as a possible means of crime, suicide, and drug-dependency reduction at the individual and community level.
利用1978年至1987年得克萨斯州27个县的数据表明,饮用水供应中锂含量很少或不含锂的县,自杀、杀人及强奸的发生率显著高于锂含量在70至170微克/升之间的县;在对人口密度进行校正后,差异仍具有统计学意义(p小于0.01)。抢劫、入室盗窃和盗窃发生率的相应关联在统计学上也具有显著意义,p小于0.05。这些结果表明,锂在市政供水可能出现的水平上,对自杀和暴力犯罪行为具有调节作用。对得克萨斯州各县饮用水锂含量与1981年至1986年鸦片、可卡因及其衍生物(吗啡、海洛因和可待因)持有逮捕率的比较,也产生了具有统计学意义的负相关,而对于大麻持有、酒后驾车和醉酒的报告逮捕率,未观察到显著或一致的关联。这些结果表明,低剂量的锂对人类行为总体上具有有益影响,这可能与锂作为一种营养必需微量元素的功能有关。在通过对高危人群进行对照实验得到证实之前,建议通过补充增加人体锂摄入量,或对饮用水进行锂化处理,作为在个人和社区层面减少犯罪、自杀和药物依赖的一种可能手段。