一例发生于肺部的T/null间变性大细胞淋巴瘤。
A case of T/null anaplastic large cell lymphoma arising in lung.
作者信息
Cerimagić Zenaida, Guska Safet, Banjanović Bedrudin
机构信息
Department of Thoracic Surgery, University of Sarajevo, Clinics Center, Sarajevo, Bosnia and Herzegovina.
出版信息
Bosn J Basic Med Sci. 2006 Aug;6(3):34-7. doi: 10.17305/bjbms.2006.3141.
Anaplastic large cell lymphoma (ALCL) is a rare non-Hodgkin, T-cell lymphoma, representing only 2-3% of all lymphoid neoplasm's in adults according to World Health Organization (WHO). CD30 antigen-positive, large neoplastic cells characterize ALCL. We present here a 46-year-old male with pulmonary ALCL previously diagnosed with Hodgkin disease. Microscopically, atypical bi-and multinucleated cells with frequent mitoses were present. The neoplastic cells were large and had clear cytoplasm, large vesicular nuclei, and prominent nucleoli. Immunophenotypic analysis revealed LCA, vimentin and CD30 positivity. ALK immunostaining was negative. Immunohistochemical profile was consistent with ALK negative ALCL. The progression of Hodgkin lymphoma to aggressive non-Hodgkin lymphoma (ALCL in this case) is well known entity. After the diagnosis was established, our patient immediately had been referred to the Department of Hematology in order to get appropriate chemotherapy, necessary in such cases.
间变性大细胞淋巴瘤（ALCL）是一种罕见的非霍奇金T细胞淋巴瘤，根据世界卫生组织（WHO）的数据，在成人所有淋巴瘤中仅占2%-3%。CD30抗原阳性的大肿瘤细胞是ALCL的特征。我们在此报告一名46岁男性，患有肺部ALCL，此前被诊断为霍奇金病。显微镜下可见非典型的双核和多核细胞，有频繁的有丝分裂。肿瘤细胞较大，细胞质清晰，细胞核呈大泡状，核仁突出。免疫表型分析显示LCA、波形蛋白和CD30呈阳性。ALK免疫染色为阴性。免疫组化特征与ALK阴性的ALCL一致。霍奇金淋巴瘤进展为侵袭性非霍奇金淋巴瘤（本例为ALCL）是一种众所周知的情况。确诊后，我们的患者立即被转诊至血液科，以便接受此类病例所需的适当化疗。
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