Maltaris Theodoros, Boehm Daniel, Dittrich Ralf, Seufert Rudolf, Koelbl Heinz
Department of Obstetrics and Gynecology, Johannes Gutenberg University, Mainz University Hospital, Langenbeckstrasse 1, 55124 Mainz, Germany.
Gynecol Oncol. 2006 Dec;103(3):1109-21. doi: 10.1016/j.ygyno.2006.08.003. Epub 2006 Sep 25.
Aggressive chemotherapy and radiotherapy or radical oncological surgery in young women with cancer has greatly enhanced these patients' life expectancy, but these treatments often cause infertility or premature ovarian failure due to a massive destruction of the ovarian reserve. The objective of this review is to discuss the effect of the various cancer treatments on fertility and present the various fertility sparing operations and fertility preservation strategies.
An extensive survey of the most up-to-date literature was performed.
This review discusses the impact of current cancer treatment on fertility potential and the various surgical and assisted-reproduction innovations available today for the most common cancers in young women. Although the ability to retain reproductive potential is becoming a major quality-of-life factor in an increasing number of young female cancer survivors, they are still being poorly counseled with regard to the negative impact of the treatment on their fertility and on their options for fertility preservation.
As the emerging discipline of fertility preservation is steadily attracting increasing interest, developments in the near future promise to be very exciting. However, in everyday routine work, better interdisciplinary cooperation between gynecological and pediatric oncologists, surgeons, immunologists, and endocrinologists is necessary so that individualized options for fertility preservation can be offered in advance of surgical procedures or cancer treatments.
对年轻癌症女性进行积极的化疗、放疗或根治性肿瘤手术极大地提高了这些患者的预期寿命，但这些治疗常常因卵巢储备的大量破坏而导致不孕或卵巢早衰。本综述的目的是讨论各种癌症治疗对生育能力的影响，并介绍各种保留生育功能的手术和生育力保存策略。
对最新文献进行了广泛的调查。
本综述讨论了当前癌症治疗对生育潜力的影响，以及当今针对年轻女性最常见癌症的各种手术和辅助生殖创新方法。尽管保留生殖潜力的能力正日益成为越来越多年轻女性癌症幸存者生活质量的一个主要因素，但在治疗对其生育能力的负面影响以及生育力保存选择方面，她们仍未得到充分的咨询。
随着新兴的生育力保存学科逐渐引起越来越多的关注，预计在不久的将来会有非常令人兴奋的发展。然而，在日常工作中，妇科和儿科肿瘤学家、外科医生、免疫学家和内分泌学家之间需要更好的跨学科合作，以便在手术或癌症治疗之前就能提供个性化的生育力保存方案。
