Maltaris Theodoros, Beckmann Matthias W, Dittrich Ralf
Department of Obstetrics and Gynecology, Erlangen University Hospital, University of Erlangen-Nuremberg, Erlangen, Germany.
In Vivo. 2009 Jan-Feb;23(1):123-30.
Young female cancer patients are still being poorly counseled with regard to the negative impact of treatment on their fertility and on their options for fertility preservation. Today, many possibilities exist for fertility preservation, such as ovarian suppression with GnRH analogues, ovarian tissue cryopreservation, in vitro maturation or IVF after ovulation induction with aromatase inhibitors. A pregnancy after cancer treatment does not seem to limit the prognosis. This review focuses on both the effect of cancer treatments on fertility and on the various assisted-reproduction innovations that are available to provide the cancer patient with the option of future pregnancies. It is currently a time of uncertainty and revolution concerning the role of ovarian suppression and other fertility preservation measures in the management of early breast cancer, but developments in the near future promise to be very exciting.
年轻女性癌症患者在治疗对其生育能力的负面影响以及生育力保存选择方面，仍然未得到充分的咨询。如今，存在许多生育力保存的可能性，例如使用促性腺激素释放激素（GnRH）类似物进行卵巢抑制、卵巢组织冷冻保存、体外成熟或使用芳香化酶抑制剂诱导排卵后进行体外受精（IVF）。癌症治疗后的妊娠似乎并不影响预后。本综述聚焦于癌症治疗对生育能力的影响以及各种可用的辅助生殖创新方法，这些方法可为癌症患者提供未来妊娠的选择。目前，关于卵巢抑制和其他生育力保存措施在早期乳腺癌管理中的作用，正处于一个不确定和变革的时期，但在不久的将来有望取得非常令人兴奋的进展。
