骨髓细胞修复受损心脏：从实验证据到临床希望

Repair of the damaged heart by bone marrow cells: from experimental evidence to clinical hope.

作者信息

Ang Keng-Leong, Shenje Lincoln Takura, Srinivasan Lakshmi, Galiñanes Manuel

机构信息

Cardiac Surgery Unit, Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Clinical Science Wing, Leicester, United Kingdom.

出版信息

Ann Thorac Surg. 2006 Oct;82(4):1549-58. doi: 10.1016/j.athoracsur.2006.05.047.

DOI:10.1016/j.athoracsur.2006.05.047

PMID:16996986

Abstract

Heart failure remains the leading cause of death in developed countries in spite of improvements in medical and surgical treatments. However, recent observations in experimental studies that bone marrow cells may repair cardiac tissue have offered renewed hopes for the treatment of heart failure. This optimism is further supported by encouraging results from some clinical trials, although the degree of benefits, the underlying mechanisms, and the cell types involved remain to be elucidated. This review summarizes the relevant experimental and clinical studies supporting the use of bone marrow cells in myocardial repair, as well as the controversies and challenges encountered.

摘要

尽管在内科和外科治疗方面有所改进，但心力衰竭仍是发达国家的主要死因。然而，最近在实验研究中观察到骨髓细胞可能修复心脏组织，这为心力衰竭的治疗带来了新的希望。一些临床试验的鼓舞人心的结果进一步支持了这种乐观态度，尽管益处的程度、潜在机制以及所涉及的细胞类型仍有待阐明。这篇综述总结了支持使用骨髓细胞进行心肌修复的相关实验和临床研究，以及所遇到的争议和挑战。