Bhattacharyya Indraneel, Islam Mohammed N, Yoon Thomas Y H, Green James G, Ohja Junu, Liu Jennifer J, Cohen Donald M
Department of Oral and Maxillofacial Surgery and Diagnostic Sciences, University of Florida College of Dentistry, Gainesville, FL 32610, USA.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006 Oct;102(4):469-74. doi: 10.1016/j.tripleo.2005.12.007. Epub 2006 Jul 14.
Gingival hypertrophy is a well-known and extensively documented undesirable side effect of cyclosporine in posttransplant patients. However, severe lip enlargement associated with cyclosporine is less recognized and has seldom been reported in the literature. Lip enlargement may lead to social, physical, and psychological stress, especially in the older childhood and adolescent age groups. We present a case of marked lip hypertrophy and concomitant gingival hypertrophy secondary to cyclosporine (Neoral) treatment in a pediatric bilateral lung transplant recipient. We also discuss the various side effects and treatment considerations available including more recent substitution therapy. Cyclosporine has most effectively and conclusively enabled transplantation of solid organs by reducing transplant-associated morbidity. We believe clinicians should be knowledgeable and aware of lip hypertrophy associated with cyclosporine use. This rare and less understood adverse effect should be recognized during the clinical evaluation of the posttransplant patient.
牙龈增生是移植后患者使用环孢素众所周知且有大量文献记载的不良副作用。然而，与环孢素相关的严重唇部肿大却较少被认识到，且在文献中鲜有报道。唇部肿大可能会导致社交、身体和心理压力，尤其是在儿童晚期和青少年年龄组。我们报告一例儿科双侧肺移植受者在接受环孢素（新山地明）治疗后出现明显唇部肥大并伴有牙龈增生的病例。我们还讨论了各种副作用及可用的治疗考虑因素，包括最近的替代疗法。环孢素通过降低与移植相关的发病率，最有效地并最终实现了实体器官的移植。我们认为临床医生应该了解并意识到与使用环孢素相关的唇部肥大。在对移植后患者进行临床评估时，应认识到这种罕见且了解较少的不良反应。
