Vescovi P, Savi A, Oppici A, Gennari P U
Istituto di Clinica Odontoiatrica, Università degli Studi, Parma.
Minerva Stomatol. 1996 Nov;45(11):523-32.
Cyclosporine is now the elective drug for immunosuppressive treatment in organ transplant patients. Compared to traditional immunosuppressants this molecule offers the therapeutic advantage that it does not act indiscriminately on all components of the immune system. In addition to the primary pharmacological action, cyclosporine also presents a number of undesirable effects, among which it is worth mentioning short and long-term nephrotoxicity and the development of neoplasia, in particular lymphomas. Other undesired effects of the drug are the possibility of overinfection, thrombosis, hypertension, hypertrichosis, hepatotoxicity and the development of the hypertrophic and hyperplastic gingival pathology.
环孢素现在是器官移植患者免疫抑制治疗的首选药物。与传统免疫抑制剂相比，这种分子具有治疗优势，即它不会对免疫系统的所有成分产生不加区分的作用。除了主要的药理作用外，环孢素还存在一些不良影响，其中值得一提的是短期和长期肾毒性以及肿瘤形成，特别是淋巴瘤。该药物的其他不良影响包括感染风险增加、血栓形成、高血压、多毛症、肝毒性以及肥厚性和增生性牙龈病变的发生。
