Fang Xin, Sugiyama Kenji, Akamine Soichi, Namba Hiroki
Department of Neurosurgery, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu 431-3192, Japan.
Brain Res. 2006 Nov 20;1120(1):202-10. doi: 10.1016/j.brainres.2006.08.073. Epub 2006 Sep 25.
Deep brain stimulation (DBS) improves motor performance in Parkinson's disease (PD) patients. To evaluate the effects of subthalamic nucleus (STN)-DBS on impaired motor behavior, we studied improvements in motor performance after delivery of unilateral stimulation to the STN in rats with mild and severe lesions of the nigrostriatal dopamine system caused by injecting 6-hydroxydopamine into the striatum. The rats were trained and performed motor behavioral tests including rotational behavior test, stepping test, and rotarod test before and after receiving DBS. We demonstrated that stimulation at a current strength of 200 microA, which stopped most of the D-amphetamine-induced rotational behaviors in these two groups, improved movement impairments in both the mild and severe groups and that the improvements in the mild group were significantly better than those in the severe group. More experimental and clinical studies are needed to evaluate the efficiency of STN-DBS for different stages of PD.
深部脑刺激（DBS）可改善帕金森病（PD）患者的运动表现。为评估丘脑底核（STN）-DBS对运动行为受损的影响，我们研究了向纹状体内注射6-羟基多巴胺导致黑质纹状体多巴胺系统轻度和重度损伤的大鼠单侧STN刺激后运动表现的改善情况。在接受DBS前后，对大鼠进行训练并进行运动行为测试，包括旋转行为测试、踏步测试和转棒测试。我们证明，以200微安的电流强度进行刺激，可使这两组中大多数由右旋苯丙胺诱导的旋转行为停止，改善轻度和重度组的运动障碍，且轻度组的改善明显优于重度组。需要更多的实验和临床研究来评估STN-DBS对PD不同阶段的疗效。
