Thejass P, Kuttan G
Department of Immunology, Amala Cancer Research Center, Thrissur, Kerala, India.
Immunopharmacol Immunotoxicol. 2006;28(3):443-57. doi: 10.1080/08923970600928049.
Effect of sulforaphane on cell-mediated immune (CMI) response was studied in normal as well as Ehrlich ascites tumor-bearing BALB/c mice. Administration of sulforaphane significantly enhanced natural killer (NK) cell activity in both normal as well as tumor-bearing animals, and the activity was observed earlier than in tumor-bearing control animals. Antibody-dependent cellular cytotoxicity (ADCC) also was enhanced significantly in both normal as well as tumor-bearing animals after sulforaphane administration compared with untreated control tumor-bearing animals. An early antibody-dependent complement-mediated cytotoxicity (ACC) also was observed in sulforaphane-treated normal and tumor-bearing animals. Administration of sulforaphane significantly enhanced the production of Interleukin-2 and Interferon-gamma in normal as well as tumor-bearing animals. In addition, sulforaphane significantly enhanced the proliferation of splenocytes, bone marrow cells, and thymocytes by stimulating the mitogenic potential of various mitogens such as concanavalin A, phytohaemagglutinin, poke weed mitogen, and lipopolysaccharide.
在正常以及荷艾氏腹水瘤的BALB/c小鼠中研究了萝卜硫素对细胞介导免疫（CMI）反应的影响。给予萝卜硫素后，正常小鼠和荷瘤小鼠的自然杀伤（NK）细胞活性均显著增强，且该活性比荷瘤对照动物出现得更早。与未处理的荷瘤对照动物相比，给予萝卜硫素后，正常小鼠和荷瘤小鼠的抗体依赖性细胞毒性（ADCC）也显著增强。在经萝卜硫素处理的正常小鼠和荷瘤小鼠中还观察到早期抗体依赖性补体介导的细胞毒性（ACC）。给予萝卜硫素后，正常小鼠和荷瘤小鼠中白细胞介素-2和γ-干扰素的产生均显著增加。此外，萝卜硫素通过刺激各种有丝分裂原（如刀豆球蛋白A、植物血凝素、商陆有丝分裂原和脂多糖）的促有丝分裂潜能，显著增强了脾细胞、骨髓细胞和胸腺细胞增殖。
