Osterborg A, Nilsson B, Björkholm M, Holm G, Mellstedt H
Department of Oncology (Radiumhemmet), Karolinska Hospital, Stockholm, Sweden.
Eur J Haematol. 1990 Sep;45(3):153-7. doi: 10.1111/j.1600-0609.1990.tb00443.x.
Natural killer (NK) activity and NK-related cell surface markers (CD16, CD56, CD57) of peripheral blood lymphocytes were studied in patients with multiple myeloma and MGUS (monoclonal gammopathy of undetermined significance). A strong correlation (p less than 0.0001) was found between the numbers of cells positive for the different NK cell surface markers. The proportion of CD16+ cells correlated highly to the lytic capability (lytic units/10(6) cells) of K562 cells (p less than 0.0001). High NK activity and high numbers of cells with NK-related cell surface markers were found in patients with a low tumor burden compared to controls, whereas low values were seen in patients with an advanced disease. The results indicate that NK cells might be involved in the disease process in monoclonal gammopathies, perhaps by exerting a regulatory function on the proliferating B-cell clone.
对多发性骨髓瘤和意义未明的单克隆丙种球蛋白病（MGUS）患者外周血淋巴细胞的自然杀伤（NK）活性及NK相关细胞表面标志物（CD16、CD56、CD57）进行了研究。发现不同NK细胞表面标志物阳性细胞数量之间存在强相关性（p<0.0001）。CD16+细胞比例与K562细胞的裂解能力（裂解单位/10⁶细胞）高度相关（p<0.0001）。与对照组相比，肿瘤负荷低的患者NK活性高，且具有NK相关细胞表面标志物的细胞数量多，而病情进展的患者NK活性和细胞数量值较低。结果表明，NK细胞可能参与了单克隆丙种球蛋白病的疾病过程，可能是通过对增殖的B细胞克隆发挥调节作用。
