Nishikawa K, Saito S, Morii T, Hamada K, Ako H, Narita N, Ichijo M, Kurahayashi M, Sugamura K
Department of Obstetrics and Gynecology, Nara Medical University, Japan.
Int Immunol. 1991 Aug;3(8):743-50. doi: 10.1093/intimm/3.8.743.
Most human peripheral blood natural killer (NK) cells express the phenotype CD16+CD56+. However, a very minor subset of NK cells express CD16-CD56+, and these NK cells bear both interleukin 2 receptor (IL-2R)alpha (p55) and IL-2R beta (p75) (high affinity IL-2 receptors). In this report, we demonstrate that in human early pregnancy decidua--an interface between maternal immunocompetent cells and fetus (placenta)--abundant (approximately 83%) CD16-CD56+ NK cells with high affinity IL-2 receptors were present, and these cells responded to low amounts of IL-2 (4.5 pM). These CD16-CD56+ NK cells significantly expressed an early activation antigen, CD69, in vivo, whereas peripheral CD16-CD56+ NK cells did not express CD69. These findings suggest that CD16-CD56+ NK cells in early pregnancy decidua may be activated in vivo, and may play an important role in immunoregulation during early pregnancy. Also, decidual lymphocytes may be useful materials to study the mechanism of MHC-unrestricted cytotoxicity of this type of NK cells.
大多数人外周血自然杀伤（NK）细胞表达CD16+CD56+表型。然而，一小部分NK细胞表达CD16-CD56+，这些NK细胞同时表达白细胞介素2受体（IL-2R）α（p55）和IL-2Rβ（p75）（高亲和力IL-2受体）。在本报告中，我们证明在人类早孕蜕膜——母体免疫活性细胞与胎儿（胎盘）的界面——存在大量（约83%）具有高亲和力IL-2受体的CD16-CD56+NK细胞，并且这些细胞对低剂量的IL-2（4.5 pM）有反应。这些CD16-CD56+NK细胞在体内显著表达早期激活抗原CD69，而外周血CD16-CD56+NK细胞不表达CD69。这些发现表明早孕蜕膜中的CD16-CD56+NK细胞可能在体内被激活，并可能在早孕期间的免疫调节中发挥重要作用。此外，蜕膜淋巴细胞可能是研究此类NK细胞MHC非限制性细胞毒性机制的有用材料。
