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从海洋苔藓虫类红苔藓虫未培养的微生物共生体中分离出两个聚酮合酶基因片段。

Isolation of two polyketide synthase gene fragments from the uncultured microbial symbiont of the marine bryozoan Bugula neritina.

作者信息

Lopanik Nicole B, Targett Nancy M, Lindquist Niels

机构信息

Graduate College of Marine Studies, University of Delaware, Lewes 19958, USA.

出版信息

Appl Environ Microbiol. 2006 Dec;72(12):7941-4. doi: 10.1128/AEM.01277-06. Epub 2006 Sep 22.

DOI:10.1128/AEM.01277-06
PMID:16997977
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1694266/
Abstract

"Candidatus Endobugula sertula," the uncultured microbial symbiont of the bryozoan Bugula neritina, produces ecologically and biomedically important polyketide metabolites called bryostatins. We isolated two gene fragments from B. neritina larvae that have high levels of similarity to polyketide synthase genes. These gene fragments are clearly associated with the symbiont and not with the host.

摘要

“暂定内共生布氏菌”（“Candidatus Endobugula sertula”）是苔藓虫类红藻（Bugula neritina）中一种无法人工培养的微生物共生体，它能产生具有重要生态和生物医药意义的聚酮化合物代谢产物，即苔藓抑素。我们从红藻幼虫中分离出了两个基因片段，它们与聚酮合酶基因具有高度相似性。这些基因片段显然与共生体相关，而非与宿主相关。

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Evolutionary implications of bacterial polyketide synthases.细菌聚酮合酶的进化意义
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