Simoncic Paul D, McGlade C Jane, Tremblay Michel L
The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada.
Can J Physiol Pharmacol. 2006 Jul;84(7):667-75. doi: 10.1139/y06-012.
It has recently been demonstrated that the protein tyrosine phosphatase (PTP) PTP1B and the T-cell PTP (TC-PTP) target several substrates involved in immune cell signaling. Recent data have furthered the view of these 2 PTP members as key regulators of the immune response. This review will focus on the substrate specificities of PTP1B and TC-PTP and their roles in immune cell signaling, and will discuss some new data implicating PTP1B and TC-PTP in myeloid development.
最近有研究表明，蛋白酪氨酸磷酸酶（PTP）PTP1B和T细胞PTP（TC-PTP）作用于多个参与免疫细胞信号传导的底物。最近的数据进一步支持了将这两个PTP成员视为免疫反应关键调节因子的观点。本综述将聚焦于PTP1B和TC-PTP的底物特异性及其在免疫细胞信号传导中的作用，并讨论一些表明PTP1B和TC-PTP参与髓系发育的新数据。
