Galbussera A, Tagliabue E, Frigo M, Apale P, Ferrarese C, Appollonio I
Neurology Section, Department of Neurosciences, University of Milan Bicocca S. Gerardo Hospital, Via Donizetti 106, I-20052, Monza (MI), Italy.
Neurol Sci. 2006 Sep;27(4):278-80. doi: 10.1007/s10072-006-0684-x.
Chickenpox may lead to several different neurological complications, but optic neuritis has rarely been described; in particular, only one case of isolated bilateral anterior optic neuritis (AON) in an immune-competent adult has so far been reported. We describe a second case of this type and consider similarities and differences between our patient and all other cases of AON following chickenpox. Then, we discuss the therapeutic role of steroids and advance the hypothesis of different pathogenetic pathways in immune-competent and immune-compromised subjects.
水痘可能会引发多种不同的神经并发症,但视神经炎鲜有报道;特别是,迄今为止仅报告过一例免疫功能正常的成年人孤立性双侧前部视神经炎(AON)病例。我们描述了此类的第二例病例,并探讨了我们的患者与水痘后所有其他AON病例之间的异同。然后,我们讨论了类固醇的治疗作用,并提出了免疫功能正常和免疫功能低下受试者中不同发病机制途径的假设。