Raju T N, Kumar C Sanat, Kanth V Rajani, Ramana B Venkata, Reddy P Uma Maheswara, Suryanarayana P, Reddy G Bhanuprakash
Physiology Division, Department of Zoology, Osmania University, Hyderabad, India.
Indian J Exp Biol. 2006 Sep;44(9):733-9.
Natural dietary ingredients are known for their antioxidant activity. Of such, curcumin, the active principle of turmeric, at 0.01% in the diet proved as pro-oxidative in galactose-induced cataract in vivo. The purpose of this study was to investigate the effect of vitamin E (VE), a well-known antioxidant, in combination with curcumin on the onset and maturation of galactose induced cataract. Periodic slit-lamp microscope examination indicated that in combination with vitamin-E, 0.01% curcumin (G-IV) delayed the onset and maturation of galactose-induced cataract. Biochemical analyses revealed that combined treatment of 0.01% curcumin and vitamin-E diet exhibited an efficient antioxidant effect, as it inhibited lipid peroxidation and contributed to a distinct rise in reduced glutathione content. The results indicate that natural dietary ingredients are effective in combination rather than the individual administration as they are complementing each other in reducing the risk of galactose induced cataract.
天然膳食成分以其抗氧化活性而闻名。其中，姜黄素作为姜黄的活性成分，在饮食中含量为0.01%时，在体内半乳糖诱导的白内障中被证明具有促氧化作用。本研究的目的是探讨著名的抗氧化剂维生素E（VE）与姜黄素联合使用对半乳糖诱导的白内障发生和成熟的影响。定期裂隙灯显微镜检查表明，0.01%姜黄素与维生素E联合使用（G-IV）可延缓半乳糖诱导的白内障的发生和成熟。生化分析显示，0.01%姜黄素与维生素E联合饮食治疗表现出有效的抗氧化作用，因为它抑制了脂质过氧化，并导致还原型谷胱甘肽含量显著增加。结果表明，天然膳食成分联合使用比单独使用更有效，因为它们在降低半乳糖诱导的白内障风险方面相互补充。
