Shono Y, Toubai T, Ota S, Ibata M, Mashiko S, Hirate D, Miura Y, Umehara S, Toyoshima N, Tanaka J, Asaka M, Imamura M
Department of Hematology and Oncology, Hokkaido University Graduate School of Medicine, Kita-ku, Sapporo, Japan.
Clin Lab Haematol. 2006 Oct;28(5):351-4. doi: 10.1111/j.1365-2257.2006.00809.x.
A 33-year-old woman underwent unrelated cord blood transplantation (U-CBT) for myelodysplastic syndrome (MDS)-related secondary AML. She showed impressive increases in the number of CD19+ B cells in bone marrow and CD19+27-IgD+ B cells in peripheral blood from about 1 month to 3 months after U-CBT. The serum level of IL-6 temporarily increased after transplantation, and this increase seemed to be correlated with the expansion of CD19+ B cells. Although, compared with BMT, little is known about the kinetics of hematological and immunological reconstitution in U-CBT, there was initial B-cell recovery after CBT as some described. This B cell recovery may be associated with a high number of B-cell precursors present in cord blood (CB). The phenomenon of naïve B lymphocyte expansion that we found might be associated with a high number of B-cell precursors present in CB.
一名33岁女性因骨髓增生异常综合征（MDS）相关的继发性急性髓系白血病接受了非亲缘脐血移植（U-CBT）。在U-CBT后约1个月至3个月，她骨髓中CD19+B细胞以及外周血中CD19+27-IgD+B细胞数量显著增加。移植后血清白细胞介素-6（IL-6）水平暂时升高，这种升高似乎与CD19+B细胞的扩增相关。尽管与骨髓移植（BMT）相比，U-CBT中血液学和免疫重建的动力学知之甚少，但正如一些人所描述的，CBT后有早期B细胞恢复。这种B细胞恢复可能与脐血（CB）中存在大量B细胞前体有关。我们发现的幼稚B淋巴细胞扩增现象可能与CB中存在大量B细胞前体有关。
