Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA.
Biol Blood Marrow Transplant. 2012 Jun;18(6):930-6. doi: 10.1016/j.bbmt.2011.11.015. Epub 2011 Nov 20.
Early after umbilical cord blood transplantation, patients show marked differences in bone marrow (BM) hematogone percentages. Little is known about whether these differences are clinically relevant. We hypothesized that early recovery of hematogones may be associated with improved transplantation outcomes. BM aspirates were assessed from 88 patients with acute myeloid leukemia by two independent reviewers at day 21 and 100 after umbilical cord blood transplantation. Interobserver variability for BM hematogone percentages at these time points showed correlation coefficients of 0.83 and 0.98, respectively (P ≤ .01 for both). A high percentage of hematogones at day 21 was associated with less acute graft-versus-host disease grade 3 to 4 (P = .01). At day 100, a high percentage of BM hematogones was associated with improved overall survival (P = .02) and lower treatment-related mortality (P ≤ .01). This study shows that BM hematogone percentages may be useful prognostic indicators in patients with acute myeloid leukemia after umbilical cord blood transplantation and should be routinely reported in BM differential counts.
脐带血移植后早期，患者骨髓（BM）造血细胞百分比存在明显差异。目前尚不清楚这些差异是否具有临床意义。我们假设造血细胞的早期恢复可能与改善移植结果有关。通过两位独立的观察者，在脐带血移植后第 21 天和第 100 天，对 88 例急性髓系白血病患者的 BM 抽吸物进行评估。这两个时间点的 BM 造血细胞百分比的观察者间变异性的相关系数分别为 0.83 和 0.98（均 P ≤.01）。第 21 天造血细胞百分比较高与较少的急性移植物抗宿主病 3 至 4 级（P =.01）相关。第 100 天，BM 造血细胞百分比较高与总生存率提高（P =.02）和治疗相关死亡率降低（P ≤.01）相关。这项研究表明，BM 造血细胞百分比可能是脐带血移植后急性髓系白血病患者有用的预后指标，应在 BM 差异计数中常规报告。
