骨髓造血祖细胞对急性髓系白血病患者脐带血移植结局的影响。
Impact of bone marrow hematogones on umbilical cord blood transplantation outcomes in patients with acute myeloid leukemia.
机构信息
Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA.
出版信息
Biol Blood Marrow Transplant. 2012 Jun;18(6):930-6. doi: 10.1016/j.bbmt.2011.11.015. Epub 2011 Nov 20.
Abstract
Early after umbilical cord blood transplantation, patients show marked differences in bone marrow (BM) hematogone percentages. Little is known about whether these differences are clinically relevant. We hypothesized that early recovery of hematogones may be associated with improved transplantation outcomes. BM aspirates were assessed from 88 patients with acute myeloid leukemia by two independent reviewers at day 21 and 100 after umbilical cord blood transplantation. Interobserver variability for BM hematogone percentages at these time points showed correlation coefficients of 0.83 and 0.98, respectively (P ≤ .01 for both). A high percentage of hematogones at day 21 was associated with less acute graft-versus-host disease grade 3 to 4 (P = .01). At day 100, a high percentage of BM hematogones was associated with improved overall survival (P = .02) and lower treatment-related mortality (P ≤ .01). This study shows that BM hematogone percentages may be useful prognostic indicators in patients with acute myeloid leukemia after umbilical cord blood transplantation and should be routinely reported in BM differential counts.
摘要
脐带血移植后早期，患者骨髓（BM）造血细胞百分比存在明显差异。目前尚不清楚这些差异是否具有临床意义。我们假设造血细胞的早期恢复可能与改善移植结果有关。通过两位独立的观察者，在脐带血移植后第 21 天和第 100 天，对 88 例急性髓系白血病患者的 BM 抽吸物进行评估。这两个时间点的 BM 造血细胞百分比的观察者间变异性的相关系数分别为 0.83 和 0.98（均 P ≤.01）。第 21 天造血细胞百分比较高与较少的急性移植物抗宿主病 3 至 4 级（P =.01）相关。第 100 天，BM 造血细胞百分比较高与总生存率提高（P =.02）和治疗相关死亡率降低（P ≤.01）相关。这项研究表明，BM 造血细胞百分比可能是脐带血移植后急性髓系白血病患者有用的预后指标，应在 BM 差异计数中常规报告。
相似文献
1
Impact of bone marrow hematogones on umbilical cord blood transplantation outcomes in patients with acute myeloid leukemia.骨髓造血祖细胞对急性髓系白血病患者脐带血移植结局的影响。
Biol Blood Marrow Transplant. 2012 Jun;18(6):930-6. doi: 10.1016/j.bbmt.2011.11.015. Epub 2011 Nov 20.
2
GRFS and CRFS in alternative donor hematopoietic cell transplantation for pediatric patients with acute leukemia.供者来源不同的造血干细胞移植在儿童急性白血病中的应用：GRFS 与 CRFS 的比较
Blood Adv. 2019 May 14;3(9):1441-1449. doi: 10.1182/bloodadvances.2018030171.
3
Mobilized peripheral blood stem cells compared with bone marrow as the stem cell source for unrelated donor allogeneic transplantation with reduced-intensity conditioning in patients with acute myeloid leukemia in complete remission: an analysis from the Acute Leukemia Working Party of the European Group for Blood and Marrow Transplantation.动员外周血干细胞与骨髓作为干细胞来源用于完全缓解的急性髓系白血病患者的非亲缘供体异基因移植的减低强度预处理：来自欧洲血液和骨髓移植学会急性白血病工作组的分析。
Biol Blood Marrow Transplant. 2012 Sep;18(9):1422-9. doi: 10.1016/j.bbmt.2012.02.013. Epub 2012 Mar 20.
4
Quantitation of hematogones at the time of engraftment is a useful prognostic indicator in allogeneic hematopoietic stem cell transplantation.移植时造血祖细胞的定量是异基因造血干细胞移植中一个有用的预后指标。
Blood. 2013 Jan 31;121(5):840-8. doi: 10.1182/blood-2012-02-409607. Epub 2012 Dec 11.
5
Outcomes of transplantation of unrelated donor umbilical cord blood and bone marrow in children with acute leukaemia: a comparison study.无关供者脐血与骨髓移植治疗儿童急性白血病的疗效：一项比较研究。
Lancet. 2007 Jun 9;369(9577):1947-54. doi: 10.1016/S0140-6736(07)60915-5.
6
Engraftment kinetics and graft failure after single umbilical cord blood transplantation using a myeloablative conditioning regimen.采用清髓性预处理方案进行单份脐血移植后的植入动力学及移植物失败情况
Haematologica. 2014 Sep;99(9):1509-15. doi: 10.3324/haematol.2014.109280. Epub 2014 Jun 27.
7
Hematopoietic stem-cell transplantation using unrelated cord-blood versus matched sibling marrow in pediatric bone marrow failure syndrome: one center's experience.儿童骨髓衰竭综合征中使用无关脐血与匹配同胞骨髓进行造血干细胞移植：一个中心的经验。
Pediatr Transplant. 1999 Nov;3(4):315-21. doi: 10.1034/j.1399-3046.1999.00062.x.
8
Superior GVHD-free, relapse-free survival for G-BM to G-PBSC grafts is associated with higher MDSCs content in allografting for patients with acute leukemia.对于急性白血病患者，GVHD 无复发生存率优于 G-BM 到 G-PBSC 移植物，这与同种异体移植中更高的髓系抑制细胞含量有关。
J Hematol Oncol. 2017 Jul 4;10(1):135. doi: 10.1186/s13045-017-0503-2.
9
Similar outcomes of allogeneic hematopoietic cell transplantation from unrelated donor and umbilical cord blood vs. sibling donor for pediatric acute myeloid leukemia: Multicenter experience in China.中国多中心经验：无关供者和脐血与同胞供者的异基因造血细胞移植治疗儿童急性髓系白血病的相似结局
Pediatr Transplant. 2015 Jun;19(4):413-21. doi: 10.1111/petr.12475. Epub 2015 Apr 22.
10
Outcomes after related and unrelated umbilical cord blood transplantation for hereditary bone marrow failure syndromes other than Fanconi anemia.亲缘与非亲缘脐血移植治疗非范可尼贫血遗传性骨髓衰竭综合征的结局。
Haematologica. 2011 Jan;96(1):134-41. doi: 10.3324/haematol.2010.027839. Epub 2010 Nov 11.
引用本文的文献
1
Analytical Appraisal of Hematogones in B-ALL MRD Assessment Using Multidimensional Dot-Plots by Multiparametric Flow Cytometry: A Critical Review and Update.使用多参数流式细胞术的多维点图对B淋巴细胞白血病微小残留病评估中造血前体细胞的分析评估：批判性综述与更新
Indian J Hematol Blood Transfus. 2024 Jan;40(1):12-24. doi: 10.1007/s12288-023-01696-5. Epub 2023 Sep 16.
2
Prognostic Value of Hematogones in Patients With Hematopoietic Disorders After Allogeneic Hematopoietic Stem Cell Transplantation: A Systematic Review and Meta-Analysis.异基因造血干细胞移植后造血系统疾病患者中造血前体细胞的预后价值：一项系统评价和荟萃分析
Cureus. 2023 Oct 17;15(10):e47184. doi: 10.7759/cureus.47184. eCollection 2023 Oct.
3
Hematogones: The Supreme Mimicker and a Cytomorphological Confounder in Acute Lymphoblastic Leukemia.原始造血细胞：急性淋巴细胞白血病中最具迷惑性的模仿者及细胞形态学混淆因素
J Lab Physicians. 2022 Oct 20;15(2):212-216. doi: 10.1055/s-0042-1757586. eCollection 2023 Jun.
4
The prognostic significance of hematogones and CD34+ myeloblasts in bone marrow for adult B-cell lymphoblastic leukemia without minimal residual disease.无微小残留病的成人 B 细胞淋巴母细胞白血病骨髓中造血祖细胞和 CD34+原始粒细胞的预后意义。
Sci Rep. 2019 Dec 23;9(1):19722. doi: 10.1038/s41598-019-56126-2.
5
Quantification of marrow hematogones following autologous stem cell transplant in adult patients with plasma cell myeloma or diffuse large B-cell lymphoma and correlation with outcome.成年浆细胞骨髓瘤或弥漫性大B细胞淋巴瘤患者自体干细胞移植后骨髓造血前体细胞的定量分析及其与预后的相关性。
Leuk Lymphoma. 2018 Apr;59(4):958-966. doi: 10.1080/10428194.2017.1352094. Epub 2017 Jul 21.
6
Hematogones: a sensitive prognostic factor for Chinese adult patients with acute myeloid leukemia.造血前体细胞：中国成年急性髓系白血病患者的一个敏感预后因素。
Curr Oncol. 2016 Apr;23(2):e123-30. doi: 10.3747/co.23.2877. Epub 2016 Apr 13.
7
[Prognostic value of bone marrow hematogones in childhood B-lineage acute lymphoblastic leukemia].[儿童B系急性淋巴细胞白血病中骨髓造血前体细胞的预后价值]
Zhongguo Dang Dai Er Ke Za Zhi. 2016 Apr;18(4):292-6. doi: 10.7499/j.issn.1008-8830.2016.04.002.
8
Infusion of CD3/CD28 costimulated umbilical cord blood T cells at the time of single umbilical cord blood transplantation may enhance engraftment.在单份脐带血移植时输注经CD3/CD28共刺激的脐带血T细胞可能会增强植入。
Am J Hematol. 2016 May;91(5):453-60. doi: 10.1002/ajh.24303. Epub 2016 Apr 4.
9
Multiparameter Flow Cytometry to Detect Hematogones and to Assess B-lymphocyte clonality in Bone Marrow Samples from Patients with Non-Hodgkin Lymphomas.采用多参数流式细胞术检测非霍奇金淋巴瘤患者骨髓样本中的造血前体细胞并评估B淋巴细胞克隆性
Hematol Rep. 2014 Jun 26;6(2):5381. doi: 10.4081/hr.2014.5381. eCollection 2014 Apr 22.
10
Prognostic significance of flow cytometric residual disease, dysregulated neutrophils/monocytes, and hematogones in adult acute myeloid leukemia in first remission.流式细胞术检测的残留病、失调的中性粒细胞/单核细胞及原始造血细胞在成人急性髓系白血病首次缓解期的预后意义
Int J Hematol. 2014 Mar;99(3):296-304. doi: 10.1007/s12185-014-1525-y. Epub 2014 Jan 31.
本文引用的文献
1
WHO classification of tumours of haematopoietic and lymphoid tissues in 2008: an overview.2008年世界卫生组织造血与淋巴组织肿瘤分类概述
Pathologica. 2010 Jun;102(3):83-7.
2
Hematogones: a new prognostic factor for acute myeloblastic leukemia.造血祖细胞：急性髓细胞白血病的一个新的预后因素。
Blood. 2011 Jan 27;117(4):1315-8. doi: 10.1182/blood-2010-07-295378. Epub 2010 Nov 15.
3
Early lymphocyte recovery and outcomes after umbilical cord blood transplantation (UCBT) for hematologic malignancies.造血系统恶性肿瘤患者行脐带血移植后早期淋巴细胞恢复及其结局。
Biol Blood Marrow Transplant. 2011 Jun;17(6):831-40. doi: 10.1016/j.bbmt.2010.08.022. Epub 2010 Sep 8.
4
Relapse risk after umbilical cord blood transplantation: enhanced graft-versus-leukemia effect in recipients of 2 units.脐带血移植后的复发风险：2单位移植受者的移植物抗白血病效应增强
Blood. 2009 Nov 5;114(19):4293-9. doi: 10.1182/blood-2009-05-220525. Epub 2009 Aug 25.
5
Allogeneic cord blood transplantation in children with hematological malignancies: a long-term follow-up single-center study.异基因脐血移植治疗儿童血液系统恶性肿瘤：一项长期随访的单中心研究。
Pediatr Hematol Oncol. 2009 Jun;26(4):165-74. doi: 10.1080/08880010902773040.
6
Intraclass correlations: uses in assessing rater reliability.组内相关系数：在评估评分者可靠性中的应用。
Psychol Bull. 1979 Mar;86(2):420-8. doi: 10.1037//0033-2909.86.2.420.
7
Umbilical cord blood transplantation after nonmyeloablative conditioning: impact on transplantation outcomes in 110 adults with hematologic disease.非清髓性预处理后的脐带血移植：对110例血液病成年患者移植结局的影响
Blood. 2007 Oct 15;110(8):3064-70. doi: 10.1182/blood-2007-04-067215. Epub 2007 Jun 14.
8
Expansion of B cell precursors after unrelated cord blood transplantation for an adult patient.一名成年患者接受非亲缘脐血移植后B细胞前体的扩增
Bone Marrow Transplant. 2007 Aug;40(3):283-5. doi: 10.1038/sj.bmt.1705714. Epub 2007 May 28.
9
Abnormal expansion of naïve B lymphocytes after unrelated cord blood transplantation--a case report.非亲缘脐血移植后幼稚B淋巴细胞异常扩增——一例报告
Clin Lab Haematol. 2006 Oct;28(5):351-4. doi: 10.1111/j.1365-2257.2006.00809.x.
10
Maturation-associated immunophenotypic abnormalities in bone marrow B-lymphocytes in myelodysplastic syndromes.骨髓增生异常综合征中骨髓B淋巴细胞成熟相关的免疫表型异常
Leuk Res. 2006 Jan;30(1):9-16. doi: 10.1016/j.leukres.2005.05.019. Epub 2005 Jul 7.
Zotero 插件