莱姆病螺旋体的伯氏疏螺旋体补体调节蛋白获取表面蛋白1在人体内表达，并诱导针对非变性结构决定簇的抗体反应。
Borrelia burgdorferi complement regulator-acquiring surface protein 1 of the Lyme disease spirochetes is expressed in humans and induces antibody responses restricted to nondenatured structural determinants.
作者信息
Rossmann Evelyn, Kitiratschky Veronique, Hofmann Heidelore, Kraiczy Peter, Simon Markus M, Wallich Reinhard
机构信息
Institute for Immunology, University of Heidelberg, Im Neuenheimer Feld 305, D-69120 Heidelberg, Germany.
出版信息
Infect Immun. 2006 Dec;74(12):7024-8. doi: 10.1128/IAI.01028-06. Epub 2006 Sep 25.
Abstract
Borrelia burgdorferi complement regulator-acquiring surface protein 1 (CRASP-1), the dominant factor H and FHL-1-binding protein of the Lyme disease spirochete B. burgdorferi, is implicated in pathogen persistence and was recently reported to be nonimmunogenic in humans. Here we show that serum samples from Lyme disease patients contain antibodies with exclusive specificity for nondenatured structural determinants of CRASP-1.
摘要
伯氏疏螺旋体补体调节蛋白获取表面蛋白1（CRASP-1）是莱姆病螺旋体伯氏疏螺旋体中主要的因子H和FHL-1结合蛋白，与病原体的持续存在有关，最近有报道称其在人类中无免疫原性。在此，我们表明莱姆病患者的血清样本中含有对CRASP-1非变性结构决定簇具有特异性的抗体。
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