Pichard A L, Kaplan J C
C R Acad Hebd Seances Acad Sci D. 1975 Feb 3;280(5):673-6.
Three forms of cyclic AMP phosphodiesterase from human platelets are resolved upon sucrose gradient centrifugation : 2.5S (monomer), 4.8S (dimer) and 7S (tetramer). They are interconvertible and form an association-dissociation equilibrium depending on the concentration of enzyme. The dissociated form has a high Km for cyclic AMP (Km : 3-5.10(-4) M) whereas the associated form has a low Km (Km : 3-5.10(-5) M).
2.5S（单体）、4.8S（二聚体）和7S（四聚体）。它们可以相互转化，并根据酶的浓度形成缔合-解离平衡。解离形式对环磷酸腺苷具有高Km值（Km：3 - 5×10⁻⁴ M），而缔合形式具有低Km值（Km：3 - 5×10⁻⁵ M）。
