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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Morimoto A, Sakata Y, Watanabe T, Murakami N

Department of Physiology, Yamaguchi University School of Medicine, Japan.

J Physiol. 1990 Jul;426:117-26. doi: 10.1113/jphysiol.1990.sp018129.

We investigated the effect of intravenous, intracerebroventricular and intrapreoptic injections of human recombinant granulocyte colony stimulating factor (GCSF) on body temperature and acute phase responses in the rabbit, including changes in the plasma concentration of iron, zinc, copper and fibrinogen and in circulating leucocyte count. 2. Neither intravenous nor intracerebroventricular injection of GCSF had any effect on the body temperature. 3. Both the intravenous and the intracerebroventricular injections of GCSF induced a dose-dependent increase in the circulating leucocyte count but neither affected the plasma concentration of iron, zinc, copper and fibrinogen. Furthermore, intrapreoptic injection of GCSF produced leucocytosis but had no effect on the red blood cell count. 4. The present results suggest that GCSF induces leucocytosis through its action on both the peripheral target organs and the central nervous system.

我们研究了静脉内、脑室内和视前区内注射人重组粒细胞集落刺激因子（GCSF）对兔体温和急性期反应的影响，包括血浆中铁、锌、铜和纤维蛋白原浓度以及循环白细胞计数的变化。2. 静脉内或脑室内注射GCSF对体温均无任何影响。3. 静脉内和脑室内注射GCSF均诱导循环白细胞计数呈剂量依赖性增加，但均不影响血浆中铁、锌、铜和纤维蛋白原的浓度。此外，视前区内注射GCSF可引起白细胞增多，但对红细胞计数无影响。4. 目前的结果表明，GCSF通过其对外周靶器官和中枢神经系统的作用诱导白细胞增多。

Morimoto A, Sakata Y, Watanabe T, Murakami N

Department of Physiology, Yamaguchi University School of Medicine, Japan.

J Physiol. 1990 Jul;426:117-26. doi: 10.1113/jphysiol.1990.sp018129.

We investigated the effect of intravenous, intracerebroventricular and intrapreoptic injections of human recombinant granulocyte colony stimulating factor (GCSF) on body temperature and acute phase responses in the rabbit, including changes in the plasma concentration of iron, zinc, copper and fibrinogen and in circulating leucocyte count. 2. Neither intravenous nor intracerebroventricular injection of GCSF had any effect on the body temperature. 3. Both the intravenous and the intracerebroventricular injections of GCSF induced a dose-dependent increase in the circulating leucocyte count but neither affected the plasma concentration of iron, zinc, copper and fibrinogen. Furthermore, intrapreoptic injection of GCSF produced leucocytosis but had no effect on the red blood cell count. 4. The present results suggest that GCSF induces leucocytosis through its action on both the peripheral target organs and the central nervous system.

我们研究了静脉内、脑室内和视前区内注射人重组粒细胞集落刺激因子（GCSF）对兔体温和急性期反应的影响，包括血浆中铁、锌、铜和纤维蛋白原浓度以及循环白细胞计数的变化。2. 静脉内或脑室内注射GCSF对体温均无任何影响。3. 静脉内和脑室内注射GCSF均诱导循环白细胞计数呈剂量依赖性增加，但均不影响血浆中铁、锌、铜和纤维蛋白原的浓度。此外，视前区内注射GCSF可引起白细胞增多，但对红细胞计数无影响。4. 目前的结果表明，GCSF通过其对外周靶器官和中枢神经系统的作用诱导白细胞增多。