参与兔子发热时伴随的急性期反应发展的脑区。

Brain regions involved in the development of acute phase responses accompanying fever in rabbits.

Morimoto A, Murakami N, Nakamori T, Sakata Y, Watanabe T

Department of Physiology, Yamaguchi University School of Medicine, Japan.

J Physiol. 1989 Sep;416:645-57. doi: 10.1113/jphysiol.1989.sp017782.

Abstract

The effects of microinjection of rabbit endogenous pyrogen and human recombinant interleukin-1 alpha on rectal temperature and acute phase responses were extensively examined in forty different brain regions of rabbits. The acute phase responses that were investigated were the changes in plasma levels of iron, zinc and copper concentration and the changes in circulating leucocyte count. 2. The rostral hypothalamic regions, such as nucleus broca ventralis, preoptic area and anterior hypothalamic region, responded to the microinjection of endogenous pyrogen or interleukin-1 by producing both fever and acute phase responses. 3. The microinjection of endogenous pyrogen or interleukin-1 into the rostral hypothalamic regions significantly decreased the plasma levels of iron and zinc concentration 8 and 24 h after injection. The circulating leucocyte count increased 8 h after injection. However, neither the injections of endogenous pyrogen nor interleukin-1 affected the number of red blood cells. 4. The present results show that the rostral hypothalamic regions respond directly to endogenous pyrogen or interleukin-1 with the consequent development of fever and acute phase responses.

摘要

在兔子的四十个不同脑区广泛研究了微量注射兔内源性热原和人重组白细胞介素-1α对直肠温度和急性期反应的影响。所研究的急性期反应包括血浆中铁、锌和铜浓度的变化以及循环白细胞计数的变化。2. 下丘脑前部区域，如布罗卡腹侧核、视前区和下丘脑前部区域，对内源性热原或白细胞介素-1的微量注射产生发热和急性期反应。3. 向下丘脑前部区域微量注射内源性热原或白细胞介素-1在注射后8小时和24小时显著降低血浆中铁和锌的浓度。注射后8小时循环白细胞计数增加。然而，内源性热原和白细胞介素-1的注射均未影响红细胞数量。4. 目前的结果表明，下丘脑前部区域直接对内源性热原或白细胞介素-1作出反应，随之出现发热和急性期反应。