城市空气污染会使易感患者的血浆纤维蛋白原和纤溶酶原激活物抑制剂-1水平升高。
Urban air pollution increases plasma fibrinogen and plasminogen activator inhibitor-1 levels in susceptible patients.
作者信息
Su Ta-Chen, Chan Chang-Chuan, Liau Chiau-Suong, Lin Lian-Yu, Kao Hsian-Li, Chuang Kai-Jen
机构信息
Institute of Occupational Medicine and Industrial Hygiene, College of Public Health, National Taiwan University, Taipei, Taiwan.
出版信息
Eur J Cardiovasc Prev Rehabil. 2006 Oct;13(5):849-52. doi: 10.1097/01.hjr.0000219116.25415.c4.
BACKGROUND
The cardiovascular effects on fibrinolytic activity by urban air pollution are still unknown.
METHODS
Paired fasting blood samples during high and low air pollution days in Taipei were taken from a panel of 49 patients with coronary heart disease or multiple risk factors to study their fibrinolytic and inflammatory response to urban air pollution. Paired t-tests and mixed-effects models were used to determine the air pollution effects.
RESULTS
Patients' plasma plasminogen activator inhibitor-1 levels were significantly increased when hourly concentrations of particulate matter with diameters less than 10 microm (PM10) were greater than 100 microg/m during the period 0800 to 1800 h.
CONCLUSION
Urban air pollution has an adverse effect on plasma fibrinolytic function in a susceptible population.
背景
城市空气污染对纤溶活性的心血管影响尚不清楚。
方法
从49例冠心病患者或具有多种危险因素的患者中采集台北市空气污染高峰期和低谷期的空腹配对血样，以研究其对城市空气污染的纤溶和炎症反应。采用配对t检验和混合效应模型来确定空气污染的影响。
结果
当08:00至18:00期间直径小于10微米的颗粒物（PM10）每小时浓度大于100微克/立方米时，患者血浆纤溶酶原激活物抑制剂-1水平显著升高。
结论
城市空气污染对易感人群的血浆纤溶功能有不利影响。
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