空气污染及其他心脏功能环境调节因素。
Air Pollution and Other Environmental Modulators of Cardiac Function.
机构信息
Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner College of Medicine, Columbus, Ohio, USA.
College of Nursing, The Ohio State University, Columbus, Ohio, USA.
出版信息
Compr Physiol. 2017 Sep 12;7(4):1479-1495. doi: 10.1002/cphy.c170017.
Abstract
Cardiovascular disease (CVD) is the leading cause of death in developed regions and a worldwide health concern. Multiple external causes of CVD are well known, including obesity, diabetes, hyperlipidemia, age, and sedentary behavior. Air pollution has been linked with the development of CVD for decades, though the mechanistic characterization remains unknown. In this comprehensive review, we detail the background and epidemiology of the effects of air pollution and other environmental modulators on the heart, including both short- and long-term consequences. Then, we provide the experimental data and current hypotheses of how pollution is able to cause the CVD, and how exposure to pollutants is exacerbated in sensitive states. Published 2017. Compr Physiol 7:1479-1495, 2017.
摘要
心血管疾病（CVD）是发达地区的主要死亡原因，也是全球关注的健康问题。多种已知的心血管疾病外部病因，包括肥胖、糖尿病、高血脂、年龄和久坐行为。几十年来，空气污染与 CVD 的发展有关，尽管其机制特征尚不清楚。在这篇全面的综述中，我们详细介绍了空气污染和其他环境调节剂对心脏的影响的背景和流行病学，包括短期和长期后果。然后，我们提供了实验数据和当前的假设，说明污染是如何导致 CVD 的，以及在敏感状态下，污染物的暴露是如何加剧的。2017 年出版。综合生理学 7:1479-1495,2017。
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