[紫苏叶不同部位提取物对大鼠血液流变学参数的影响]

[Effects of extracts from different parts of Folium perillae (L.) Britt. on Hemorrheological parameters in rats].

作者信息

Xu Zaipin, Deng Xiaoyan, Men Jiying, Feng Xuejian, Lu Zhanjun, Yang Qinghua, Yao Biqiong

机构信息

Key Lab for Biomechanics & Tissue Engineering of Ministry of Education, Chongqing University, China.

出版信息

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2006 Aug;23(4):762-5.

PMID:17002102

Abstract

In order to provide experimental data for the development and application of drug in clinic, we determined the effects of extracts from different parts of folium perillae (L. ) Britt. on hemorheological parameters, extracted from leaves (folium perillae), seeds (fructus perillae) and peduncles (caulis perillae). The results showed that all extracts from different parts of folium perillae (L. ) Britt. can significantly reduce the whole blood viscosity at low shear rate (10 s(-1)), erythrocyte aggregation index, erythrocyte electrophoresis index (P<0.05), and the whole blood reductive viscosity at low shear rate (10 s(-1)) (P<0.01). Extracts from folium perillae and caulis perillae can significantly decrease erythrocyte deformation index (P<0.05), whereas extracts from fructus perillae can not. Extracts from fructus perillae and caulis perillae can significantly decrease plasma viscosity at low shear rate(10 s(-1)), but extracts of folium perillae can not. Aspirin can only decrease the whole blood reductive viscosity at low shear rate and plasma viscosity (P<0.05). All extracts from different parts of folium perillae (L. ) Britt. had no significant effects on hematocrit, erythrocyte rigidity index, fibrinogen concentration , the whole blood viscosity and the whole blood reductive viscosity at middle and high shear rate (60 s(-1),120 s(-1)).

摘要

为了给药物在临床的研发和应用提供实验数据，我们测定了紫苏叶不同部位提取物对血液流变学参数的影响，这些提取物分别取自叶片（紫苏叶）、种子（紫苏子）和茎（紫苏梗）。结果表明，紫苏叶不同部位的所有提取物均可显著降低低切变率（10 s⁻¹）下的全血黏度、红细胞聚集指数、红细胞电泳指数（P<0.05）以及低切变率（10 s⁻¹）下的全血还原黏度（P<0.01）。紫苏叶和紫苏梗提取物可显著降低红细胞变形指数（P<0.05），而紫苏子提取物则无此作用。紫苏子和紫苏梗提取物可显著降低低切变率（10 s⁻¹）下的血浆黏度，而紫苏叶提取物则不能。阿司匹林仅能降低低切变率下的全血还原黏度和血浆黏度（P<0.05）。紫苏叶不同部位的所有提取物对血细胞比容、红细胞刚性指数、纤维蛋白原浓度、中高切变率（60 s⁻¹、120 s⁻¹）下的全血黏度和全血还原黏度均无显著影响。