Al-Gahtany Mubarak, Horvath Eva, Kovacs Kalman
Department of Neurosurgery, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada.
Hormones (Athens). 2003 Jul-Sep;2(3):149-58. doi: 10.14310/horm.2002.1195.
Pituitary hyperplasia is rare, difficult to diagnose and sometimes controversial. The hyperplasia could be physiologic which is usually reversible, or pathologic which varies in presentation from incidental to tumor like lesion with and without hormonal disturbance. Any pituitary cell is capable of undergoing hyperplasia in the presence of the right stimuli. In this article we summarize the various pathologic and morphologic features of each subtype of pituitary hyperplasia, give an account of the molecular, hormonal and cellular basis of this condition and outline its clinical significance, differential diagnosis and prognosis.
垂体增生罕见，诊断困难，有时存在争议。增生可能是生理性的，通常可逆；也可能是病理性的，表现多样，从偶然发现到类似肿瘤的病变，可伴有或不伴有激素紊乱。在适当刺激下，任何垂体细胞都可能发生增生。本文总结了垂体增生各亚型的各种病理和形态学特征，阐述了该病症的分子、激素和细胞基础，并概述了其临床意义、鉴别诊断和预后。
