Edwards Linda, Morris Kevin P, Siddiqui Ameen, Harrington Deborah, Barron David, Brawn William
Department of Paediatric Intensive Care, Birmingham Children's Hospital NHS Trust, Steelhouse Lane, Birmingham, B4 6NH, United Kingdom.
Arch Dis Child Fetal Neonatal Ed. 2007 May;92(3):F210-4. doi: 10.1136/adc.2006.094664. Epub 2006 Sep 26.
The Norwood procedure is the first stage palliative procedure for hypoplastic left heart syndrome (HLHS). Traditionally the pulmonary circulation has been supplied via a modified Blalock Taussig (BT) shunt but a recent modification, adopted in some UK centres, substitutes a conduit between right ventricle and pulmonary arteries (RV-PA conduit). It is argued that this will result in a more favourable balance between pulmonary and systemic circulations.
To compare the early postoperative haemodynamic profile between patients undergoing a BT shunt or an RV-PA conduit.
Retrospective review in a tertiary referral PICU of 51 children with HLHS undergoing the Norwood procedure with either a BT shunt (Group 1; n = 23) or an RV-PA conduit (Group 2; n = 28). Data items were extracted at 10 set time points in the initial 96 h, postoperatively.
Diastolic BP was significantly lower in Group 1 (p<0.001) with a trend towards a higher systolic BP and no difference in mean BP. No between-group differences were found in markers of pulmonary blood flow (PaO2, PaCO2, PaO2/FiO2 ratio), or in markers of systemic blood flow (blood lactate, oxygen extraction ratio), or in estimated ratio of pulmonary:systemic blood flow (Qp:Qs). Despite lower diastolic blood pressure in Group 1 renal and hepatic function did not differ over five post-operative days between groups.
With the exception of a higher diastolic blood pressure in the RV-PA conduit group, we found no difference in the early haemodynamic profile between patients undergoing an RV-PA conduit or a BT shunt.
诺伍德手术是治疗左心发育不全综合征(HLHS)的第一阶段姑息性手术。传统上,肺循环是通过改良的布莱洛克-陶西格(BT)分流术来供应的,但英国一些中心最近采用了一种改良方法,即用右心室与肺动脉之间的管道(RV-PA管道)来替代。有人认为,这将使肺循环和体循环之间达到更有利的平衡。
比较接受BT分流术或RV-PA管道手术患者术后早期的血流动力学情况。
对一家三级转诊儿科重症监护病房(PICU)中51例接受诺伍德手术的HLHS患儿进行回顾性研究,其中23例接受BT分流术(第1组),28例接受RV-PA管道手术(第2组)。术后在最初96小时内的10个固定时间点提取数据项。
第1组的舒张压显著较低(p<0.001),收缩压有升高趋势,平均血压无差异。在肺血流量指标(动脉血氧分压、动脉血二氧化碳分压、动脉血氧分压/吸入氧分数比)、体循环血流量指标(血乳酸、氧摄取率)或肺循环与体循环血流量估计比值(Qp:Qs)方面,两组之间没有差异。尽管第1组舒张压较低,但两组术后五天的肾功能和肝功能并无差异。
除RV-PA管道组舒张压较高外,我们发现接受RV-PA管道手术或BT分流术的患者术后早期血流动力学情况没有差异。