Ståhle L, Collin A K, Ungerstedt U
Department of Pharmacology, Karolinska Institute, Stockholm, Sweden.
Naunyn Schmiedebergs Arch Pharmacol. 1990 Aug;342(2):136-40. doi: 10.1007/BF00166955.
The effects of halothane anaesthesia on striatal extracellular levels of dopamine, dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA) and 5-hydroxyindolacetic acid (5HIAA) were investigated in microdialysis experiments. Induction of anaesthesia was accompanied by a rapid increase in dopamine levels and a slower increase in DOPAC and HVA. 5HIAA was not affected. The reduction of dopamine levels induced by apomorphine 0.05 mg/kg appeared with a shorter latency in conscious rats than in anaesthetised rats but the maximum decrease was unaffected by anaesthesia. The decreases in dopamine and DOPAC induced by alpha-methyl-p-tyrosine 50 mg/kg were affected in opposite directions by halothane: the dopamine reduction was more pronounced while the DOPAC reduction was less pronounced in anaesthetized than in conscious animals. In no case was a qualitative shift in the response observed. It is concluded that halothane may influence the levels of dopamine as well as the response to dopaminergic drugs.
在微透析实验中，研究了氟烷麻醉对纹状体细胞外多巴胺、二羟基苯乙酸（DOPAC）、高香草酸（HVA）和5-羟吲哚乙酸（5HIAA）水平的影响。麻醉诱导伴随着多巴胺水平的快速升高以及DOPAC和HVA的缓慢升高。5HIAA不受影响。0.05mg/kg阿扑吗啡诱导的多巴胺水平降低在清醒大鼠中出现的潜伏期比麻醉大鼠短，但最大降幅不受麻醉影响。50mg/kgα-甲基-p-酪氨酸诱导的多巴胺和DOPAC降低在氟烷作用下呈现相反方向的变化：与清醒动物相比，麻醉动物中多巴胺降低更明显，而DOPAC降低则不那么明显。在任何情况下均未观察到反应的定性变化。结论是氟烷可能影响多巴胺水平以及对多巴胺能药物的反应。
