Hanson J M, Kooistra H S, Mol J A, Teske E, Meij B P
Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 8, PO Box 80.154, NL-3508 TD Utrecht, The Netherlands.
J Endocrinol. 2006 Sep;190(3):601-9. doi: 10.1677/joe.1.06782.
The 6-h plasma profiles of adrenocorticotropic hormone (ACTH), cortisol, alpha-melanocyte-stimulating hormone (alpha-MSH), and GH were studied in 17 dogs with pituitary-dependent hyperadrenocorticism (PDH) before and after hypophysectomy. The aim of the study was to investigate the relation between the hormone profile characteristics and recurrence of PDH after surgery. The hormones were secreted in a pulsatile fashion. The basal plasma cortisol concentration and area under the curve (AUC) for cortisol were significantly higher in the PDH cases than in eight controls. The characteristics of the plasma profiles of ACTH and alpha-MSH were not significantly different between the PDH cases and the controls. In the PDH cases, less GH was secreted in pulses than in the controls, but the difference was not significant. The basal plasma cortisol concentration, the AUC for ACTH and cortisol, and the pulse frequency of ACTH and cortisol decreased significantly after hypophysectomy for the group of PDH cases. The basal plasma concentrations of ACTH and alpha-MSH, the AUC for alpha-MSH, and the characteristics of the plasma GH profiles of the PDH cases remained unchanged after hypophysectomy. No pulses of alpha-MSH were observed after hypophysectomy. The co-occurrence between the ACTH and cortisol pulses decreased significantly with hypophysectomy. The postoperative pulse frequency of ACTH was the only characteristic with predictive value for the recurrence of PDH after hypophysectomy. The results of this study demonstrate that ACTH, cortisol, alpha-MSH, and GH are secreted in a pulsatile fashion in dogs with PDH. Hypophysectomy effectively reduces the secretion of ACTH and cortisol. The presence of ACTH pulses after hypophysectomy is a risk factor for the recurrence of hyperadrenocorticism.
对17只垂体依赖性肾上腺皮质功能亢进（PDH）犬在垂体切除术前和术后研究了促肾上腺皮质激素（ACTH）、皮质醇、α-黑素细胞刺激素（α-MSH）和生长激素（GH）的6小时血浆浓度变化曲线。本研究的目的是探讨激素浓度变化曲线特征与术后PDH复发之间的关系。这些激素以脉冲方式分泌。PDH病例的基础血浆皮质醇浓度和皮质醇曲线下面积（AUC）显著高于8只对照犬。PDH病例与对照犬之间ACTH和α-MSH的血浆浓度变化曲线特征无显著差异。在PDH病例中，脉冲分泌的GH比对照犬少，但差异不显著。垂体切除术后，PDH组的基础血浆皮质醇浓度、ACTH和皮质醇的AUC以及ACTH和皮质醇的脉冲频率显著降低。垂体切除术后，PDH病例的ACTH和α-MSH基础血浆浓度、α-MSH的AUC以及血浆GH浓度变化曲线特征保持不变。垂体切除术后未观察到α-MSH脉冲。垂体切除术后，ACTH和皮质醇脉冲的同时出现显著减少。垂体切除术后ACTH的脉冲频率是PDH复发的唯一具有预测价值的特征。本研究结果表明，PDH犬的ACTH、皮质醇、α-MSH和GH以脉冲方式分泌。垂体切除术有效减少了ACTH和皮质醇的分泌。垂体切除术后ACTH脉冲的存在是肾上腺皮质功能亢进复发的危险因素。
