体重减轻和营养干预对2型糖尿病患者动脉僵硬度的影响。

Effect of weight loss and nutritional intervention on arterial stiffness in type 2 diabetes.

作者信息

Barinas-Mitchell Emma, Kuller Lewis H, Sutton-Tyrrell Kim, Hegazi Refaat, Harper Patricia, Mancino Juliet, Kelley David E

机构信息

Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

出版信息

Diabetes Care. 2006 Oct;29(10):2218-22. doi: 10.2337/dc06-0665.

DOI:10.2337/dc06-0665

PMID:17003296

Abstract

OBJECTIVE

There is increased stiffness of the large central arteries in type 2 diabetic patients, and obesity is a risk factor. However, the effect of intentional weight loss on arterial stiffness is uncertain, and the purpose of the current study was to assess this effect.

RESEARCH DESIGN AND METHODS

Arterial stiffness was assessed by measuring aortic pulse wave velocity (aPWV) at baseline and at completion of a 1-year weight loss intervention. Metabolic control of type 2 diabetes was also appraised.

RESULTS

Mean weight loss at 1 year in 38 volunteers with type 2 diabetes was 7.8%. There were improvements in HbA1c, LDL cholesterol, homeostasis model assessment of insulin resistance, and inflammatory markers (plasminogen activator inhibitor-1, tumor necrosis factor-alpha, interleukin-6, and C-reactive protein). There was also a significant improvement in aPWV at completion of weight loss intervention, from 740 to 690 cm/s (P < 0.05).

CONCLUSIONS

Moderate weight loss improves arterial stiffness in type 2 diabetes.

摘要

目的

2型糖尿病患者的大中心动脉僵硬度增加，肥胖是一个危险因素。然而，有意减肥对动脉僵硬度的影响尚不确定，本研究的目的是评估这种影响。

研究设计与方法

通过在基线时和1年减肥干预结束时测量主动脉脉搏波速度（aPWV）来评估动脉僵硬度。还评估了2型糖尿病的代谢控制情况。

结果

38名2型糖尿病志愿者1年时的平均体重减轻了7.8%。糖化血红蛋白、低密度脂蛋白胆固醇、胰岛素抵抗稳态模型评估和炎症标志物（纤溶酶原激活物抑制剂-1、肿瘤坏死因子-α、白细胞介素-6和C反应蛋白）均有所改善。减肥干预结束时，aPWV也有显著改善，从740 cm/s降至690 cm/s（P<0.05）。