Third Department of Internal Medicine, Papageorgiou Hospital, Aristotle University of Thessaloniki, GR56403 Thessaloniki, Greece.
Department of Nutritional Sciences & Dietetics, Faculty of Health Sciences, International Hellenic University, Alexander Campus, Sindos, PO Box 141, GR57400 Thessaloniki, Greece.
Nutrients. 2020 May 7;12(5):1326. doi: 10.3390/nu12051326.
Lifestyle modification is an important component of essential hypertension (EH) therapy. The aim of the Hypertension Intensive Nutrition Treatment (HINTreat) parallel, randomized controlled trial was to examine the effect of a 6-month intensive lifestyle treatment (ILT) (diet plus exercise with monthly visits) compared to the usual care. A total of 76 adults with stage 1 EH were randomized (38 in each group). Dietary analysis, anthropometry, physical activity, biochemical and urine profile, blood pressure (BP), asymmetric dimethylarginine (ADMA), central hemodynamics, β-stiffness index and carotid intima media-thickness were evaluated. The dietary inflammatory index (DII) was calculated for each participant from the intake of 29 nutrients/food components. At the end of the trial, participants in the ILT group reduced their 24h urinary Na excretion ( ≤ 0.001), daytime systolic BP ( ≤ 0.048) and mean carotid β-stiffness index ( ≤ 0.005) and ameliorated their lipidemic profile compared to the standard care. Univariate analysis for the total sample showed a strong association between DII and ADMA levels (β = 0.089, ≤ 0.01). ILT is effective in improving the inflammatory components of the diet and selected cardiometabolic parameters, including arterial stiffness.
生活方式改变是治疗原发性高血压（EH）的重要组成部分。高血压强化营养治疗（HINTreat）平行、随机对照试验的目的是检验 6 个月强化生活方式治疗（ILT）（饮食加运动，每月就诊）与常规护理相比的效果。共有 76 名 1 期 EH 成人被随机分组（每组 38 人）。评估了膳食分析、人体测量学、体力活动、生化和尿液分析、血压（BP）、不对称二甲基精氨酸（ADMA）、中心血液动力学、β-硬度指数和颈动脉内膜中层厚度。从 29 种营养素/食物成分的摄入中计算了每位参与者的膳食炎症指数（DII）。在试验结束时，与标准护理相比，ILT 组参与者的 24 小时尿钠排泄量（≤0.001）、白天收缩压（≤0.048）和平均颈动脉β-硬度指数（≤0.005）降低，血脂谱得到改善。对总样本的单变量分析显示，DII 与 ADMA 水平之间存在很强的关联（β=0.089，≤0.01）。ILT 可有效改善饮食中的炎症成分和某些心血管代谢参数，包括动脉僵硬。
