McCarthy Douglas D, Summers-Deluca Leslie, Vu Frances, Chiu Sidney, Gao Yunfei, Gommerman Jennifer L
Department of Immunology, University of Toronto, 1 King's College Circle Toronto, Ontario, Canada.
Immunol Res. 2006;35(1-2):41-54. doi: 10.1385/IR:35:1:41.
The first studies of mice deficient in lymphotoxin-alpha (LTalpha), LTbeta and LTbetaR revealed the seminal discovery that the LTbetaR signaling is critical for the development of lymph nodes and Peyer's patches during embryogenesis. Since these initial findings, it is increasingly appreciated that signaling through the lymphotoxin-beta receptor (LTbetaR) plays a key role in numerous biological processes in the adult animal, including the maintenance of specialized stromal cell types and the homeostatic control of chemokine expression within the lymphoid tissues. A major focus of our laboratory is to understand the relevance of LTbetaR signaling in initiating immune responses both dependent and independent of its role in maintaining the organization of lymphoid tissues. This review will therefore explore new possibilities for how this complex pathway regulates humoral and cellular immunity.
对缺乏淋巴毒素-α（LTα）、淋巴毒素-β（LTβ）和淋巴毒素-β受体（LTβR）的小鼠进行的首批研究揭示了一项具有开创性的发现，即LTβR信号传导在胚胎发育过程中对淋巴结和派尔集合淋巴结的形成至关重要。自这些初步发现以来，人们越来越认识到通过淋巴毒素-β受体（LTβR）进行的信号传导在成年动物的众多生物学过程中发挥着关键作用，包括维持特定的基质细胞类型以及对淋巴组织内趋化因子表达的稳态控制。我们实验室的一个主要重点是了解LTβR信号传导在启动免疫反应中的相关性，这既依赖于其在维持淋巴组织组织结构中的作用，也独立于该作用。因此，本综述将探讨这一复杂途径如何调节体液免疫和细胞免疫的新可能性。
