Hofmann R, Schreiber G A, Willich N, Westhaus R, Bögl K W
Institut für Wasser-, Boden- und Lufthygiene des Bundesgesundheitsamtes, Langen.
Strahlenther Onkol. 1990 Oct;166(10):688-95.
The radiation-induced increase of serum amylase is investigated in 41 patients following either whole body irradiation or irradiation of the head- and neck-region. The radiation treatment caused a dose-independent serum amylase increase up to 80 times of the preirradiation measured in controls. This increase can only be induced if the salivary glands are within the radiation field. An isoenzyme analysis differentiated between salivary and pancreatic amylase. It was shown that also in case of whole body irradiation pancreatic proteins either contribute only to a small extent to the increase or show no recognizable change. Although great variations in radiation response remain, the increase of serum amylase produced by salivary glands is highly significant and serves as a bioindicator for radiation exposures.
对41例接受全身照射或头颈部照射的患者进行了辐射诱导血清淀粉酶升高的研究。放射治疗导致血清淀粉酶剂量非依赖性升高，最高可达对照组照射前测量值的80倍。只有当唾液腺位于辐射野内时，才能诱导这种升高。同工酶分析区分了唾液淀粉酶和胰腺淀粉酶。结果表明，在全身照射的情况下，胰腺蛋白对升高的贡献要么很小，要么没有明显变化。尽管辐射反应仍有很大差异，但唾液腺产生的血清淀粉酶升高非常显著，可作为辐射暴露的生物指标。
