Shoyele Sunday A, Cawthorne Simon
3M Health Care Ltd, Morley Street, Loughborough, LE11 1EP, UK.
Adv Drug Deliv Rev. 2006 Oct 31;58(9-10):1009-29. doi: 10.1016/j.addr.2006.07.010. Epub 2006 Aug 12.
Formulation of biopharmaceuticals for pulmonary delivery is faced with the challenge of producing particles with the optimal properties for deep lung deposition without altering the native conformation of these molecules. Traditional techniques such as milling are continuously being improved while newer and more advanced techniques such as spray drying, spray freeze drying and supercritical fluid technology are being developed so as to optimize pulmonary delivery of biopharmaceuticals. While some of these techniques are quite promising, some are harsh and impracticable. Method scale up, cost-effectiveness and safety issues are important factors to be considered in the choice of a technique. This paper reviews the presently developed techniques for particle engineering biopharmaceuticals.
要制备出具有最佳性质的颗粒，以便在不改变这些分子天然构象的情况下实现肺部深部沉积。诸如研磨等传统技术在不断改进，同时诸如喷雾干燥、喷雾冷冻干燥和超临界流体技术等更新、更先进的技术也在不断发展，以优化生物制药的肺部给药。虽然其中一些技术颇具前景，但有些技术却很苛刻且不实用。方法放大、成本效益和安全性问题是选择技术时需要考虑的重要因素。本文综述了目前已开发的用于生物制药颗粒工程的技术。
